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IBBR operates a suite of core facilities that provide access to state of the art technology for basic and translational research. The core facilities are located within IBBR Shady Grove and IBBR College Park. Many of the cores are managed in collaboration with our research partners.
- The DNA Sequencing Facility, located in IBBR College Park, provides DNA (Sanger) sequencing service with user-provided template, electrophoretic fraction of reactions, and automated base-calling. An Applied Biosystems DNA sequencer (model 3730) is the principal instrument.
- The Illumina Sequencing Facility, located in IBBR College Park, provides the University of Maryland research community (as well as off-campus customers) with access to 'Next Generation' sequencing using the Illumina HiSeq 1000 platform. Current services include DNA sequencing (DNA-seq) and Transcriptome analysis (RNA-seq)
- The Insect Transformation Facility (ITF), promotes the advancement of insect molecular science and its application to human health and welfare. Located in IBBR-Shady Grove, the ITF is an international resource for the creation of genetically modified insects, development of new modification technologies, and providing training in the use of insect modification technologies.
- The MTECH Biopharmaceutical Advancement Facility (BAF) is a translational core facility located at IBBR Shady Grove that specializes in the development of cell culture-based biopharmaceutical products. BAF is part of the Biotechnology Research and Education Program of the University of Maryland’s Technology Enterprise Institute (MTECH) The BAF is closely aligned with the Bioprocess Scale-Up Facility located in College Park.
- The Biomolecular Labeling Laboratory (BL2) is a joint facility of the National Institute of Standards and Technology (NIST) and the University of Maryland (UMD). The laboratory provides the infrastructure for biomolecules labeled with stable isotopes for advanced biophysical and bioanalytical research applications. The BL2 enables users to label proteins and other biomolecules for structural and biophysical studies including, but not limited to, small angle neutron scattering (SANS), nuclear magnetic resonance (NMR) and mass spectrometry.
- IBBR's Plant Growth Facilities, located at IBBR Shady Grove, provide a plant transformation laboratory, an extensive suite of plant tissue culture and growth chambers, and a greenhouse suitable for transforming crop plants and model experiemental plants for a variety of uses.
- The W.M. Keck/NIST Laboratories for Biomolecular NMR include state-of –the-art magnets operating at 500MHz and 600MHz proton resonance frequencies as well as a complement of resources for research in molecular biology, x-ray crystallography, fluorescence spectroscopy, fast kinetics, calorimetry and computational science.
- The W.M. Keck/NIST X-ray Crystallography Core Facility supports IBBR’s strong research emphasis providing experience and expertise in macromolecular structural determination by X-ray crystallography and analysis of the resulting atomic structures.
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