Lecture Series: Emergence of Adaptive Immunity: The Answer to Everything

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Event Type: 
Contact Person: 
Host: 
Yuxing Li
Event Info
Date: 
Jan 25 2021 - 11:00am to 12:00pm
Location: 
Auditorium
Details
Speaker/Presenter: 
Martin Flajnik
Speaker Title: 
Professor
Speaker Affiliation: 
University of Maryland School of Medicine
Event Description: 

Emergence of Adaptive Immunity: The Answer to Everything 

Adaptive immunity in jawed vertebrates (Gnathostomes) is centered on Ig, TCR, and the MHC, as well as RAG-mediated VDJ recombination, AID-mediated somatic hypermutation, and responses initiated in secondary lymphoid tissues. All of these characteristics are present in the oldest living gnathostomes, the sharks. Interestingly, our data would argue that Ig, TCR, and MHC are derived from a primordial genetic region that can be followed by examining genome-wide duplications early in the history of the vertebrates.