NIST BMD/IBBR Seminar: E-GADS: We’ve created an Electrospray Glycopeptide Abundance Distribution Spectrum

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Event Type: 
Contact Person: 
Host: 
Mike Tarlov
Event Info
Date: 
Mar 16 2021 - 11:00am to 12:00pm
Location: 
Virtual
Details
Speaker/Presenter: 
Steve Stein
Speaker Affiliation: 
NIST
Event Description: 

Motivated by interest in the complex glycan shield on the SARS-CoV-2 Spike protein, we have undertaken a program to develop mass spectral libraries to aid in its characterization. We first extended our existing library and software to represent complex glycopeptides and then discovered an effective way to represent the site-specific distributions of N-glycans on any protein, including the 22 sites of the Spike. The evolution, future and applications of this program will be discussed.