Structural Basis of Fc-mediated Antibody Response to HIV

Printer-friendly versionPrinter-friendly versionPDF versionPDF version
Event Type: 
Contact Person: 
Event Info
Date: 
Monday, February 11, 2019 - 11:00am to 12:00pm
Location: 
Auditorium
Details
Speaker/Presenter: 
Marzena Pazgier
Speaker Affiliation: 
USUHS
Event Description: 

While a number of therapeutic options to control the progression of Human immunodeficiency virus (HIV-1) now exist, a broadly effective preventative vaccine is still not available. Through detailed structural analysis of antibodies able to induce potent Fc-mediated effector function against HIV-1 we identified a number of HIV Env epitopes (referred to as Epitope Cluster A) which have the potential to be considered as vaccine candidates. We will discuss our recent advances in defining common structural features of these potent epitope targets and the structure-based design of ID2 immunogen that stably expose the Cluster A region in the absence of other Env epitopes. ID2 induced antibody responses in BALB/c mice targeting the Cluster A region and capable of potent Fc-mediated elimination of HIV-infected cells.

Setup
IT Setup: 
Projector
Laptop
Podium
Lavalier Microphone
Wireless PPT Remote