Quorum Sensing Communication: Molecularly Connecting Cells, Their Neighbors, and Even Devices.

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TitleQuorum Sensing Communication: Molecularly Connecting Cells, Their Neighbors, and Even Devices.
Publication TypeJournal Article
Year of Publication2020
AuthorsWang, S, Payne, GF, Bentley, WE
JournalAnnu Rev Chem Biomol Eng
Date Published2020 Mar 13
ISSN1947-5446
Abstract

Quorum sensing (QS) is a molecular signaling modality that mediates molecular-based cell-cell communication. Prevalent in nature, QS networks provide bacteria with a method to gather information from the environment and make decisions based on the intel. With its ability to autonomously facilitate both inter- and intraspecies gene regulation, this process can be rewired to enable autonomously actuated, but molecularly programmed, genetic control. On the one hand, novel QS-based genetic circuits endow cells with smart functions that can be used in many fields of engineering, and on the other, repurposed QS circuitry promotes communication and aids in the development of synthetic microbial consortia. Furthermore, engineered QS systems can probe and intervene in interkingdom signaling between bacteria and their hosts. Lastly, QS is demonstrated to establish conversation with abiotic materials, especially by taking advantage of biological and even electronically induced assembly processes; such QS-incorporated biohybrid devices offer innovative ways to program cell behavior and biological function. Expected final online publication date for the , Volume 11 is June 8, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

DOI10.1146/annurev-chembioeng-101519-124728
Alternate JournalAnnu Rev Chem Biomol Eng
PubMed ID32168999