Avoidance of Self during CRISPR Immunization.

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TitleAvoidance of Self during CRISPR Immunization.
Publication TypeJournal Article
Year of Publication2020
AuthorsWeissman, JL, Stoltzfus, A, Westra, ER, Johnson, PLF
JournalTrends Microbiol
Volume28
Issue7
Pagination543-553
Date Published2020 Jul
ISSN1878-4380
Abstract

The battle between microbes and their viruses is ancient and ongoing. Clustered regularly interspaced short palindromic repeat (CRISPR) immunity, the first and, to date, only form of adaptive immunity found in prokaryotes, represents a flexible mechanism to recall past infections while also adapting to a changing pathogenic environment. Critical to the role of CRISPR as an adaptive immune mechanism is its capacity for self versus non-self recognition when acquiring novel immune memories. Yet, CRISPR systems vary widely in both how and to what degree they can distinguish foreign from self-derived genetic material. We document known and hypothesized mechanisms that bias the acquisition of immune memory towards non-self targets. We demonstrate that diversity is the rule, with many widespread but no universal mechanisms for self versus non-self recognition.

DOI10.1016/j.tim.2020.02.005
Alternate JournalTrends Microbiol.
PubMed ID32544441