Polyphosphazene immunoadjuvants: Historical perspective and recent advances.

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TitlePolyphosphazene immunoadjuvants: Historical perspective and recent advances.
Publication TypeJournal Article
Year of Publication2020
AuthorsAndrianov, AK, Langer, R
JournalJ Control Release
Volume329
Pagination299-315
Date Published2020 Dec 05
ISSN1873-4995
Abstract

The development of successful vaccines has been increasingly reliant on the use of immunoadjuvants - additives, which can enhance and modulate immune responses to vaccine antigens. Immunoadjuvants of the polyphosphazene family encompass synthetic biodegradable macromolecules, which attain in vivo activity via antigen delivery and immunostimulation mechanisms. Over the last decades, the technology has witnessed evolvement of next generation members, expansion to include various antigens and routes of administration, and progression to clinical phase. This was accompanied by gaining important insights into the mechanism of action and the development of a novel class of virus-mimicking nano-assemblies for antigen delivery. The present review evaluates in vitro and in vivo data generated to date in the context of latest advances in understanding the primary function and biophysical behavior of these macromolecules. It also provides an overview of relevant synthetic and characterization methods, macromolecular biodegradation pathways, and polyphosphazene-based multi-component, nanoparticulate, and microfabricated formulations.

DOI10.1016/j.jconrel.2020.12.001
Alternate JournalJ Control Release
PubMed ID33285104
Grant ListR01 AI132213 / AI / NIAID NIH HHS / United States