Interactive Materials for Bidirectional Redox-Based Communication.

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TitleInteractive Materials for Bidirectional Redox-Based Communication.
Publication TypeJournal Article
Year of Publication2021
AuthorsLi, J, Wang, SP, Zong, G, Kim, E, Tsao, C-Y, VanArsdale, E, Wang, L-X, Bentley, WE, Payne, GF
JournalAdv Mater
Paginatione2007758
Date Published2021 Mar 31
ISSN1521-4095
Abstract

Emerging research indicates that biology routinely uses diffusible redox-active molecules to mediate communication that can span biological systems (e.g., nervous and immune) and even kingdoms (e.g., a microbiome and its plant/animal host). This redox modality also provides new opportunities to create interactive materials that can communicate with living systems. Here, it is reported that the fabrication of a redox-active hydrogel film can autonomously synthesize a H O signaling molecule for communication with a bacterial population. Specifically, a catechol-conjugated/crosslinked 4-armed thiolated poly(ethylene glycol) hydrogel film is electrochemically fabricated in which the added catechol moieties confer redox activity: the film can accept electrons from biological reductants (e.g., ascorbate) and donate electrons to O to generate H O . Electron-transfer from an Escherichia coli culture poises this film to generate the H O signaling molecule that can induce bacterial gene expression from a redox-responsive operon. Overall, this work demonstrates that catecholic materials can participate in redox-based interactions that elicit specific biological responses, and also suggests the possibility that natural phenolics may be a ubiquitous biological example of interactive materials.

DOI10.1002/adma.202007758
Alternate JournalAdv Mater
PubMed ID33788338
Grant ListCBET#1932963 / / National Science Foundation /
CBET#1805274 / / National Science Foundation /
ECCS#1807604 / / National Science Foundation /
HDTRA1-19-0021 / / Defense Threat Reduction Agency /
SCW1710 / / Department of Energy /
CBET#1932963 / / National Science Foundation /
CBET#1805274 / / National Science Foundation /
ECCS#1807604 / / National Science Foundation /
HDTRA1-19-0021 / / Defense Threat Reduction Agency /
SCW1710 / / Department of Energy /