Immunopotentiating and Delivery Systems for HCV Vaccines.

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TitleImmunopotentiating and Delivery Systems for HCV Vaccines.
Publication TypeJournal Article
Year of Publication2021
AuthorsAndrianov, AK, Fuerst, TR
JournalViruses
Volume13
Issue6
Date Published2021 May 25
ISSN1999-4915
Abstract

Development of preventive vaccines against hepatitis C virus (HCV) remains one of the main strategies in achieving global elimination of the disease. The effort is focused on the quest for vaccines capable of inducing protective cross-neutralizing humoral and cellular immune responses, which in turn dictate the need for rationally designed cross-genotype vaccine antigens and potent immunoadjuvants systems. This review provides an assessment of the current state of knowledge on immunopotentiating compounds and vaccine delivery systems capable of enhancing HCV antigen-specific immune responses, while focusing on the synergy and interplay of two modalities. Structural, physico-chemical, and biophysical features of these systems are discussed in conjunction with the analysis of their in vivo performance. Extreme genetic diversity of HCV-a well-known hurdle in the development of an HCV vaccine, may also present a challenge in a search for an effective immunoadjuvant, as the effort necessitates systematic and comparative screening of rationally designed antigenic constructs. The progress may be accelerated if the preference is given to well-defined molecular immunoadjuvants with greater formulation flexibility and adaptability, including those capable of spontaneous self-assembly behavior, while maintaining their robust immunopotentiating and delivery capabilities.

DOI10.3390/v13060981
Alternate JournalViruses
PubMed ID34070543
PubMed Central IDPMC8227888
Grant ListR01AI132213 / NH / NIH HHS / United States