Target highlights in CASP14: analysis of models by structure providers.

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TitleTarget highlights in CASP14: analysis of models by structure providers.
Publication TypeJournal Article
Year of Publication2021
AuthorsAlexander, LT, Lepore, R, Kryshtafovych, A, Adamopoulos, A, Alahuhta, M, Arvin, AM, Bomble, YJ, Böttcher, B, Breyton, C, Chiarini, V, Chinnam, NBabu, Chiu, W, Fidelis, K, Grinter, R, Gupta, GD, Hartmann, MD, Hayes, CS, Heidebrecht, T, Ilari, A, Joachimiak, A, Kim, Y, Linares, R, Lovering, AL, Lunin, VV, Lupas, AN, Makbul, C, Michalska, K, Moult, J, Mukherjee, PK, Nutt, WSam, Oliver, SL, Perrakis, A, Stols, L, Tainer, JA, Topf, M, Tsutakawa, SE, Valdivia-Delgado, M, Schwede, T
JournalProteins
Date Published2021 Sep 25
ISSN1097-0134
Abstract

The biological and functional significance of selected CASP14 targets are described by the authors of the structures. The authors highlight the most relevant features of the target proteins and discuss how well these features were reproduced in the respective submitted predictions. The overall ability to predict three-dimensional structures of proteins has improved remarkably in CASP14, and many difficult targets were modelled with impressive accuracy. For the first time in the history of CASP, the experimentalists not only highlighted that computational models can accurately reproduce the most critical structural features observed in their targets, but also envisaged that models could serve as a guidance for further studies of biologically-relevant properties of proteins. This article is protected by copyright. All rights reserved.

DOI10.1002/prot.26247
Alternate JournalProteins
PubMed ID34561912