CASP9 results compared to those of previous CASP experiments.

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TitleCASP9 results compared to those of previous CASP experiments.
Publication TypeJournal Article
Year of Publication2011
AuthorsKryshtafovych, A, Fidelis, K, Moult, J
Volume79 Suppl 10
Date Published2011
KeywordsComputational Biology, Models, Molecular, Protein Conformation, Proteins, Sequence Alignment

The quality of structure models submitted to CASP9 is analyzed in the context of previous CASPs. Comparison methods are similar to those used in previous articles in this series, with the addition of new methods looking at model quality in regions not covered by a single best structural template, alignment accuracy, and progress for template-free models. Progress in this CASP was again modest and statistically hard to validate. Nevertheless, there are several positive trends. There is an indication of improvement in overall model quality for the midrange of template-based modeling difficulty, methods for identifying the best model from a set generated have improved, and there are strong indications of progress in the quality of template-free models of short proteins. In addition, the new examination of a model quality in regions of model not covered by the best available template reveals better performance than had previously been apparent.

Alternate JournalProteins
PubMed ID21997643
Grant ListLM07085 / LM / NLM NIH HHS / United States
R01 GM100482 / GM / NIGMS NIH HHS / United States