The multiple mechanisms of T cell receptor cross-reactivity.

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TitleThe multiple mechanisms of T cell receptor cross-reactivity.
Publication TypeJournal Article
Year of Publication2009
AuthorsYin, Y, Mariuzza, RA
JournalImmunity
Volume31
Issue6
Pagination849-51
Date Published2009 Dec 18
ISSN1097-4180
KeywordsAnimals, Antigens, Cross Reactions, Histocompatibility Antigens, Humans, Receptors, Antigen, T-Cell, T-Lymphocytes
Abstract

The ability of a single T cell to recognize the diverse peptides it encounters is based on T cell receptor crossreactivity. In this issue of Immunity, Macdonald et al. (2009) and Borbulevych et al. (2009) provide new insights into the structural principles underlying this fundamental property of T cells.

DOI10.1016/j.immuni.2009.12.002
Alternate JournalImmunity
PubMed ID20064442