Evidence for a predominant role of oxidative damage in germline mutation in mammals.

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TitleEvidence for a predominant role of oxidative damage in germline mutation in mammals.
Publication TypeJournal Article
Year of Publication2008
AuthorsStoltzfus, A
JournalMutat Res
Volume644
Issue1-2
Pagination71-3
Date Published2008 Sep 26
ISSN0027-5107
KeywordsAnimals, CpG Islands, DNA Damage, Evolution, Molecular, Germ-Line Mutation, Humans, Mammals, Models, Genetic, Oxidation-Reduction
Abstract

Spontaneous copying errors in replication often are assumed to be the main source of germline mutations in humans and other mammals. However, when laboratory data on context-dependent patterns of oxidative DNA damage are compared with patterns of mutation inferred from mammalian sequence evolution, the strength of the correlation suggests that damage is the main source of mutations. Analysis of damage susceptibility holds promise for improving models of mutational specificity.

DOI10.1016/j.mrfmmm.2008.05.003
Alternate JournalMutat. Res.
PubMed ID18597793