Cis interactions of immunoreceptors with MHC and non-MHC ligands.

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TitleCis interactions of immunoreceptors with MHC and non-MHC ligands.
Publication TypeJournal Article
Year of Publication2008
AuthorsHeld, W, Mariuzza, RA
JournalNat Rev Immunol
Date Published2008 Apr
KeywordsAnimals, B-Lymphocytes, Cytotoxicity, Immunologic, HLA Antigens, Humans, Killer Cells, Natural, Major Histocompatibility Complex, Mast Cells, Receptors, Immunologic, T-Lymphocytes

The conventional wisdom is that cell-surface receptors interact with ligands expressed on other cells to mediate cell-to-cell communication (trans interactions). Unexpectedly, it has recently been found that two classes of receptors specific for MHC class I molecules not only interact with MHC class I molecules expressed on opposing cells, but also with those on the same cell. These cis interactions are a feature of immunoreceptors that inhibit, rather than activate, cellular functions. Here, we review situations in which cis interactions have been observed, the characteristics of receptors that bind in trans and cis, and the biological roles of cis recognition.

Alternate JournalNat. Rev. Immunol.
PubMed ID18309314
PubMed Central IDPMC2491490
Grant ListAI047990 / AI / NIAID NIH HHS / United States
R01 AI047990-04 / AI / NIAID NIH HHS / United States