A search for inhibitors of S100B, a member of the S100 family of calcium-binding proteins.

Printer-friendly versionPrinter-friendly versionPDF versionPDF version
TitleA search for inhibitors of S100B, a member of the S100 family of calcium-binding proteins.
Publication TypeJournal Article
Year of Publication2007
AuthorsMarkowitz, J, Mackerell, AD, Weber, DJ
JournalMini Rev Med Chem
Volume7
Issue6
Pagination609-16
Date Published2007 Jun
ISSN1389-5575
KeywordsAnimals, Calcium, Calcium-Binding Proteins, Databases, Genetic, Feedback, Physiological, Humans, Neoplasms, Nerve Growth Factors, S100 Calcium Binding Protein beta Subunit, S100 Proteins, Tumor Suppressor Protein p53
Abstract

Typically, malignant melanoma has wild-type p53, and yet this cancer proliferates. S100B, which binds p53 and is up-regulated in melanoma, down-regulates wild-type p53 tumor suppressor function. Inhibitors of the S100B-p53 interaction were identified using computer aided drug design (CADD) combined with NMR methodologies and represent potentially new chemotherapeutics for melanoma.

Alternate JournalMini Rev Med Chem
PubMed ID17584159
Grant ListS10 RR023447 / RR / NCRR NIH HHS / United States
R01 CA107331 / CA / NCI NIH HHS / United States
GM58888 / GM / NIGMS NIH HHS / United States
CA107331 / CA / NCI NIH HHS / United States
F30-NS043916 / NS / NINDS NIH HHS / United States
S10 RR015741 / RR / NCRR NIH HHS / United States
R01 GM058888 / GM / NIGMS NIH HHS / United States