TCR recognition of peptide/MHC class II complexes and superantigens.

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TitleTCR recognition of peptide/MHC class II complexes and superantigens.
Publication TypeJournal Article
Year of Publication2007
AuthorsSundberg, EJ, Deng, L, Mariuzza, RA
JournalSemin Immunol
Volume19
Issue4
Pagination262-71
Date Published2007 Aug
ISSN1044-5323
KeywordsAntigen Presentation, Autoantigens, Autoimmunity, Bacteria, Histocompatibility Antigens Class II, HLA-DR1 Antigen, Humans, Models, Molecular, Neoplasms, Peptides, Protein Conformation, Receptors, Antigen, T-Cell, Superantigens
Abstract

Major histocompatibility complex (MHC) class II molecules display peptides to the T cell receptor (TCR). The ability of the TCR to discriminate foreign from self-peptides presented by MHC molecules is a requirement of an effective adaptive immune response. Dysregulation of this molecular recognition event often leads to a disease state. Recently, a number of structural studies have provided significant insight into several such dysregulated interactions between peptide/MHC complexes and TCR molecules. These include TCR recognition of self-peptides, which results in autoimmune reactions, and of mutant self-peptides, common in the immunosurveillance of tumors, as well as the engagement of TCRs by superantigens, a family of bacterial toxins responsible for toxic shock syndrome.

DOI10.1016/j.smim.2007.04.006
Alternate JournalSemin. Immunol.
PubMed ID17560120
PubMed Central IDPMC2949352
Grant ListAI36900 / AI / NIAID NIH HHS / United States
R21 AI055882-03 / AI / NIAID NIH HHS / United States
R37 AI036900-12 / AI / NIAID NIH HHS / United States