TCR recognition of peptide/MHC class II complexes and superantigens.

Printer-friendly versionPrinter-friendly versionPDF versionPDF version
TitleTCR recognition of peptide/MHC class II complexes and superantigens.
Publication TypeJournal Article
Year of Publication2007
AuthorsSundberg, EJ, Deng, L, Mariuzza, RA
JournalSemin Immunol
Date Published2007 Aug
KeywordsAntigen Presentation, Autoantigens, Autoimmunity, Bacteria, Histocompatibility Antigens Class II, HLA-DR1 Antigen, Humans, Models, Molecular, Neoplasms, Peptides, Protein Conformation, Receptors, Antigen, T-Cell, Superantigens

Major histocompatibility complex (MHC) class II molecules display peptides to the T cell receptor (TCR). The ability of the TCR to discriminate foreign from self-peptides presented by MHC molecules is a requirement of an effective adaptive immune response. Dysregulation of this molecular recognition event often leads to a disease state. Recently, a number of structural studies have provided significant insight into several such dysregulated interactions between peptide/MHC complexes and TCR molecules. These include TCR recognition of self-peptides, which results in autoimmune reactions, and of mutant self-peptides, common in the immunosurveillance of tumors, as well as the engagement of TCRs by superantigens, a family of bacterial toxins responsible for toxic shock syndrome.

Alternate JournalSemin. Immunol.
PubMed ID17560120
PubMed Central IDPMC2949352
Grant ListAI36900 / AI / NIAID NIH HHS / United States
R21 AI055882-03 / AI / NIAID NIH HHS / United States
R37 AI036900-12 / AI / NIAID NIH HHS / United States