Multiple paths to multispecificity.

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TitleMultiple paths to multispecificity.
Publication TypeJournal Article
Year of Publication2006
AuthorsMariuzza, RA
JournalImmunity
Volume24
Issue4
Pagination359-61
Date Published2006 Apr
ISSN1074-7613
KeywordsAnimals, Antibodies, Antibody Diversity, Antibody Formation, Antigen-Antibody Reactions, Antigens, B-Lymphocytes, Binding Sites, Antibody, Humans
Abstract

The limited primary antibody repertoire uses multiple mechanisms to account for the large number of potential antigens. In this issue of Immunity, Sethi et al. (2006) describe a new means for expanding the antibody repertoire, whereby a single antibody isomer binds diverse antigens at different regions of the binding site.

DOI10.1016/j.immuni.2006.03.009
Alternate JournalImmunity
PubMed ID16618592