Molecularly imprinted polymers for tobacco mosaic virus recognition.

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TitleMolecularly imprinted polymers for tobacco mosaic virus recognition.
Publication TypeJournal Article
Year of Publication2006
AuthorsBolisay, LD, Culver, JN, Kofinas, P
JournalBiomaterials
Volume27
Issue22
Pagination4165-8
Date Published2006 Aug
ISSN0142-9612
KeywordsBiocompatible Materials, Biosensing Techniques, Cross-Linking Reagents, Hydrogel, Hydrogels, Materials Testing, Polymers, Surface Properties, Tobacco, Tobacco Mosaic Virus, Viruses
Abstract

Molecular imprinted Polymers (MIP) targeted for Tobacco mosaic virus (TMV) have been synthesized. Batch equilibrium studies using imprinted and non-imprinted polymer hydrogels in TMV and TNV solutions were conducted to determine virus-binding capacities. TMV-imprinted hydrogels showed increased binding to TMV (8.8 mg TMV/gpolymer) compared to non-imprinted hydrogels (4.2 mg TMV/gpolymer). Furthermore, TMV-imprinted hydrogels exhibited increased binding to TMV compared to TNV, while non-imprinted hydrogels bound similar amounts of TMV or TNV. This research has demonstrated that molecular imprinting of viruses can be used to selectively induce binding of target viruses based on shape differences of their virions.

DOI10.1016/j.biomaterials.2006.03.018
Alternate JournalBiomaterials
PubMed ID16574216