MHC class I recognition by Ly49 natural killer cell receptors.

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TitleMHC class I recognition by Ly49 natural killer cell receptors.
Publication TypeJournal Article
Year of Publication2002
AuthorsNatarajan, K, Dimasi, N, Wang, J, Margulies, DH, Mariuzza, RA
JournalMol Immunol
Date Published2002 May
KeywordsAnimals, Antigens, Ly, Histocompatibility Antigens Class I, Humans, Killer Cells, Natural, Lectins, C-Type, Membrane Glycoproteins, Mice, Models, Molecular, NK Cell Lectin-Like Receptor Subfamily A, Protein Structure, Tertiary, Receptors, Immunologic, Receptors, NK Cell Lectin-Like

Natural killer (NK) cell function is regulated by NK receptors that bind either classical MHC class I (MHC-I) molecules or their structural relatives (MICA, RAE-1 and H-60). Two distinct families of NK receptors have been identified: the C-type lectin-like family (Ly49, NKG2D and CD94/NKG2) and the immunoglobulin-like family (KIRs and LIRs). Here, we describe the crystal structure of the C-type lectin-like NK receptor (Ly49A), bound to its MHC-I ligand (H-2D(d)). We also discuss results from recent mutagenesis studies of the Ly49A/H-2D(d) interaction in the context of the complex structure.

Alternate JournalMol. Immunol.
PubMed ID11955594