Structural basis of MHC class I recognition by natural killer cell receptors.

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TitleStructural basis of MHC class I recognition by natural killer cell receptors.
Publication TypeJournal Article
Year of Publication2001
AuthorsSawicki, MW, Dimasi, N, Natarajan, K, Wang, J, Margulies, DH, Mariuzza, RA
JournalImmunol Rev
Volume181
Pagination52-65
Date Published2001 Jun
ISSN0105-2896
KeywordsAmino Acid Sequence, Animals, Antigens, CD, Antigens, Ly, Binding Sites, Carrier Proteins, H-2 Antigens, Histocompatibility Antigens Class I, HLA-C Antigens, Humans, Killer Cells, Natural, Lectins, C-Type, Ligands, Macromolecular Substances, Membrane Proteins, Mice, Models, Molecular, Molecular Sequence Data, Molecular Structure, NK Cell Lectin-Like Receptor Subfamily A, Receptors, Immunologic, Receptors, KIR, Receptors, KIR2DL2, Receptors, NK Cell Lectin-Like, Sequence Homology, Amino Acid
Abstract

Natural killer (NK)-cell function is regulated by NK receptors that recognize MHC class I (MHC-I) molecules on target cells. Two structurally distinct families of NK receptors have been identified, the immunoglobulin-like family (killer cell immunoglobulin-like receptors (KIRs), leukocyte immunoglobulin-like receptors (LIRs)) and the C-type lectin-like family (Ly49, CD94/NKG2A, NKG2D, CD69). Recently, the three-dimensional structures of several NK receptors were determined, in free form or bound to MHC-I. These include those of unbound KIRs, NKG2D, CD69, LIR-1 and the CD94 subunit of the CD94/NKG2A heterodimer. Together, these structures define the basic molecular architecture of both the immunoglobulin-like and C-type lectin-like families of NK receptors. In addition, crystal structures have been reported for the complex between Ly49A and H-2Dd, and for KIR2DL2 bound to HLA-Cw3. The complex structures provide a framework for understanding MHC-I recognition by NK receptors from both families and reveal striking differences in the nature of this recognition, despite the receptors' functional similarity.

Alternate JournalImmunol. Rev.
PubMed ID11513152
Grant ListR01 AI47900 / AI / NIAID NIH HHS / United States
R37 36900 / / PHS HHS / United States