Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia.

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TitleRearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia.
Publication TypeJournal Article
Year of Publication1989
AuthorsKelman, Z, Prokocimer, M, Peller, S, Kahn, Y, Rechavi, G, Manor, Y, Cohen, A, Rotter, V
JournalBlood
Volume74
Issue7
Pagination2318-24
Date Published1989 Nov 15
ISSN0006-4971
KeywordsBlast Crisis, DNA Probes, DNA, Neoplasm, Gene Rearrangement, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Oncogene Proteins, Phosphoproteins, Polymorphism, Restriction Fragment Length, Restriction Mapping, Tumor Suppressor Protein p53
Abstract

Molecular structural analysis of the p53 gene in patients with Philadelphia chromosome-positive chronic myelogenous leukemia (CML) indicates a significant incidence of gene rearrangements in patients at either accelerated phase or blastic crisis. Southern blot analysis of genomic DNA hybridizing with either genomic or cDNA p53 specific probes indicated that 30% of the CML patients at blastic crisis phase exhibited rearrangements, mostly mapping downstream to the first non-coding exon. This is compatible with the observation that the progression of CML from the chronic to the acute phase involves frequent aberrations in chromosome 17, to which the p53 oncogene has been mapped. Therefore, we suggest that one of the pathways of development of CML to the acute phase is associated with aberrations in the p53 nuclear oncogene.

Alternate JournalBlood
PubMed ID2572286