Prostacyclin production by human umbilical vein endothelium in response to serum from patients with systemic sclerosis.

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TitleProstacyclin production by human umbilical vein endothelium in response to serum from patients with systemic sclerosis.
Publication TypeJournal Article
Year of Publication1989
AuthorsHolt, CM, Moult, J, Lindsey, N, Hughes, P, Greaves, M, Rowell, NR
JournalBr J Rheumatol
Volume28
Issue3
Pagination216-20
Date Published1989 Jun
ISSN0263-7103
KeywordsAdult, Aged, Cell Division, Endothelium, Vascular, Epoprostenol, Female, Humans, Male, Middle Aged, Reference Values, Scleroderma, Systemic, Thymidine, Time Factors, Umbilical Veins
Abstract

Sera from 29 patients with systemic sclerosis and 30 normal controls were examined for their effect on prostacyclin release by human umbilical vein endothelial cells during periods of response of 15 min and 72 h and for their effect on endothelial growth and 3H-thymidine uptake during a 72-h culture period. In contrast to previous reports, no significant differences were detected between patient and control sera in their effect on endothelial cell prostacyclin release, growth or 3H-thymidine uptake.

Alternate JournalBr. J. Rheumatol.
PubMed ID2659125
Grant List / / Wellcome Trust / United Kingdom