Anticardiolipin antibodies in systemic sclerosis: immunological and clinical associations.

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TitleAnticardiolipin antibodies in systemic sclerosis: immunological and clinical associations.
Publication TypeJournal Article
Year of Publication1988
AuthorsMalia, RG, Greaves, M, Rowlands, LM, Lawrence, AC, Hume, A, Rowell, NR, Moult, J, Holt, CM, Lindsey, N, Hughes, P
JournalClin Exp Immunol
Volume73
Issue3
Pagination456-60
Date Published1988 Sep
ISSN0009-9104
KeywordsAdult, Aged, Autoantibodies, beta-Thromboglobulin, Cardiolipins, Complement Activating Enzymes, Complement C1, Complement C1q, Female, Humans, Immunoglobulin G, Immunoglobulin M, Male, Middle Aged, Platelet Factor 4, Scleroderma, Systemic, von Willebrand Factor
Abstract

Anticardiolipin antibodies of IgG/IgM class were detected in seven of 28 patients with systemic sclerosis including five of 16 patients severely affected by extensive visceral disease. This severely affected sub-group also showed significant elevations of plasma levels of von Willebrand factor antigen in 10 cases and serum C1q binding activity in seven cases respectively. This triple association raises the possibility that multiple immunological mechanisms are involved in the pathogenesis of systemic sclerosis and its vascular lesions.

Alternate JournalClin. Exp. Immunol.
PubMed ID2974767
PubMed Central IDPMC1541778
Grant List / / Wellcome Trust / United Kingdom