Elevated von Willebrand factor antigen in systemic sclerosis: relationship to visceral disease.

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TitleElevated von Willebrand factor antigen in systemic sclerosis: relationship to visceral disease.
Publication TypeJournal Article
Year of Publication1988
AuthorsGreaves, M, Malia, RG, A Ward, M, Moult, J, Holt, CM, Lindsey, N, Hughes, P, Goodfield, M, Rowell, NR
JournalBr J Rheumatol
Volume27
Issue4
Pagination281-5
Date Published1988 Aug
ISSN0263-7103
KeywordsAdult, Aged, Antigens, Factor VIII, Female, Humans, Male, Middle Aged, Scleroderma, Systemic, von Willebrand Factor
Abstract

Plasma levels of the factor VIII complex (von Willebrand factor antigen, factor VIII coagulant and ristocetin co-factor) were measured in 28 patients with systemic sclerosis. Elevated von Willebrand factor antigen was found in 12 patients overall and in 10 of 16 patients characterized by severe extensive visceral disease, with a resulting positive correlation between the extent of visceral involvement and the plasma level of von Willebrand factor antigen (r = 0.60, p less than 0.001). Factor VIII coagulant and ristocetin co-factor levels, however, frequently failed to parallel the increases of von Willebrand factor antigen, supporting the view that these increases were due to in vivo endothelial damage. The findings suggest that vascular damage is an important aspect of the visceral lesions of systemic sclerosis.

Alternate JournalBr. J. Rheumatol.
PubMed ID3136816
Grant List / / Wellcome Trust / United Kingdom