Enhancer sequences responsible for DNase I hypersensitivity in polyomavirus chromatin.

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TitleEnhancer sequences responsible for DNase I hypersensitivity in polyomavirus chromatin.
Publication TypeJournal Article
Year of Publication1986
AuthorsBryan, PN, Folk, WR
JournalMol Cell Biol
Volume6
Issue6
Pagination2249-52
Date Published1986 Jun
ISSN0270-7306
KeywordsBase Sequence, Chromatin, Deoxyribonuclease I, DNA, Viral, Enhancer Elements, Genetic, Genes, Regulator, Nucleic Acid Conformation, Polyomavirus
Abstract

DNase I preferentially cleaves polyomavirus minichromosomes at two sites in the enhancer, each of which comprises the sequence AAGCAPuPuAAG flanked by short inverted repeats. A tandem duplication of this sequence generates an additional hypersensitive locus. Mutations which alter either the AAGCAPuPuAAG or flanking repeats diminish hypersensitivity. This region must determine the chromatin conformation recognized by DNase I.

Alternate JournalMol. Cell. Biol.
PubMed ID3023924
PubMed Central IDPMC367766
Grant ListCA 38538 / CA / NCI NIH HHS / United States