Broad HIV-1 neutralization mediated by CD4-binding site antibodies.

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TitleBroad HIV-1 neutralization mediated by CD4-binding site antibodies.
Publication TypeJournal Article
Year of Publication2007
AuthorsLi, Y, Migueles, SA, Welcher, B, Svehla, K, Phogat, A, Louder, MK, Wu, X, Shaw, GM, Connors, M, Wyatt, RT, Mascola, JR
JournalNat Med
Date Published2007 Sep
KeywordsAcquired Immunodeficiency Syndrome, Antigens, CD, Antigens, CD4, Binding Sites, Antibody, Cohort Studies, HIV Antibodies, HIV-1, Humans, Neutralization Tests

We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4-binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are elicited in some HIV-1-infected individuals, and new approaches to present this conserved region of gp120 to the immune system may result in improved vaccine immunogens.

Alternate JournalNat. Med.
PubMed ID17721546
PubMed Central IDPMC2584972
Grant ListU19 AI067854 / AI / NIAID NIH HHS / United States
U19 AI067854-03 / AI / NIAID NIH HHS / United States