ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers.

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TitleZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers.
Publication TypeJournal Article
Year of Publication2014
AuthorsPierce, BG, Wiehe, K, Hwang, H, Kim, B-H, Vreven, T, Weng, Z
JournalBioinformatics
Volume30
Issue12
Pagination1771-3
Date Published2014 Jun 15
ISSN1367-4811
KeywordsAlgorithms, Molecular Docking Simulation, Multiprotein Complexes, Protein Multimerization, Software
Abstract

SUMMARY: Protein-protein interactions are essential to cellular and immune function, and in many cases, because of the absence of an experimentally determined structure of the complex, these interactions must be modeled to obtain an understanding of their molecular basis. We present a user-friendly protein docking server, based on the rigid-body docking programs ZDOCK and M-ZDOCK, to predict structures of protein-protein complexes and symmetric multimers. With a goal of providing an accessible and intuitive interface, we provide options for users to guide the scoring and the selection of output models, in addition to dynamic visualization of input structures and output docking models. This server enables the research community to easily and quickly produce structural models of protein-protein complexes and symmetric multimers for their own analysis.

AVAILABILITY: The ZDOCK server is freely available to all academic and non-profit users at: http://zdock.umassmed.edu. No registration is required.

DOI10.1093/bioinformatics/btu097
Alternate JournalBioinformatics
PubMed ID24532726
PubMed Central IDPMC4058926
Grant ListGM084884 / GM / NIGMS NIH HHS / United States