Small-molecule inhibitors of the ERK signaling pathway: Towards novel anticancer therapeutics.

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TitleSmall-molecule inhibitors of the ERK signaling pathway: Towards novel anticancer therapeutics.
Publication TypeJournal Article
Year of Publication2011
AuthorsYap, JL, Worlikar, S, Mackerell, AD, Shapiro, P, Fletcher, S
JournalChemMedChem
Volume6
Issue1
Pagination38-48
Date Published2011 Jan 03
ISSN1860-7187
KeywordsAnimals, Antineoplastic Agents, Cell Line, Tumor, Enzyme Inhibitors, Extracellular Signal-Regulated MAP Kinases, Humans, MAP Kinase Signaling System, Mice, Neoplasms, Protein Binding, Quantitative Structure-Activity Relationship, raf Kinases, Signal Transduction, Small Molecule Libraries
DOI10.1002/cmdc.201000354
Alternate JournalChemMedChem
PubMed ID21110380
PubMed Central IDPMC3477473
Grant ListR01 CA120215 / CA / NCI NIH HHS / United States
CA120215 / CA / NCI NIH HHS / United States