Radical Scavenging Activities of Biomimetic Catechol-Chitosan Films.

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TitleRadical Scavenging Activities of Biomimetic Catechol-Chitosan Films.
Publication TypeJournal Article
Year of Publication2018
AuthorsCao, C, Kim, E, Liu, Y, Kang, M, Li, J, Yin, J-J, Liu, H, Qu, X, Liu, C, Bentley, WE, Payne, GF
Date Published2018 Jun 21
Abstract<p>Recent studies showed that melanin-mimetic catechol-chitosan films are redox-active and their ability to exchange electrons confers pro-oxidant activities for the sustained, in situ generation of reactive oxygen species for antimicrobial bandages. Here we electrofabricated catechol-chitosan films, demonstrate these films are redox-active, and show their ability to exchange electrons confers sustained radical scavenging activities that could be useful for protective coatings. Electrofabrication was performed in two steps: cathodic electrodeposition of a chitosan film followed by anodic grafting of catechol to chitosan. Spectroelectrochemical reverse engineering methods were used to characterize the catechol-chitosan films and demonstrate the films are redox-active and can donate electrons to quench oxidative free radicals and can accept electrons to quench reductive free radicals. Electrofabricated catechol-chitosan films that were peeled from the electrode were also shown to be capable of donating electrons to quench an oxidative free radical but this radical scavenging activity decayed upon depletion of electrons from the film (i.e., as the film became oxidized). However, the radical scavenging activity could be recovered by a regeneration step in which the films were contacted with the biological reducing agent ascorbic acid. These results demonstrate that catecholic materials offer important redox-based and context-dependent properties for possible applications as protective coatings.</p>
Alternate JournalBiomacromolecules
PubMed ID29928797