Structural biology of Zika virus and other flaviviruses.

Printer-friendly versionPrinter-friendly versionPDF versionPDF version
TitleStructural biology of Zika virus and other flaviviruses.
Publication TypeJournal Article
Year of Publication2018
AuthorsS Hasan, S, Sevvana, M, Kuhn, RJ, Rossmann, MG
JournalNat Struct Mol Biol
Date Published2018 01
KeywordsAnimals, Antibodies, Neutralizing, Antibodies, Viral, Cryoelectron Microscopy, Dengue Virus, Encephalitis Virus, Japanese, Female, Guillain-Barre Syndrome, Humans, Male, Mice, Microcephaly, Models, Biological, Pregnancy, Protein Conformation, United States, Virus Assembly, Virus Internalization, West Nile virus, Zika Virus, Zika Virus Infection

Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) and Japanese encephalitis (JEV) viruses. ZIKV infections have been linked to fetal microcephaly and the paralytic Guillain-Barré syndrome. This review provides a comparative structural analysis of the assembly, maturation and host-cell entry of ZIKV with other flaviviruses, especially DENV. We also discuss the mechanisms of neutralization by antibodies.

Alternate JournalNat. Struct. Mol. Biol.
PubMed ID29323278