Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates.

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TitlePost-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates.
Publication TypeJournal Article
Year of Publication2019
AuthorsBrannan, JM, He, S, Howell, KA, Prugar, LI, Zhu, W, Vu, H, Shulenin, S, Kailasan, S, Raina, H, Wong, G, Rahim, MNiaz, Banadyga, L, Tierney, K, Zhao, X, Li, Y, Holtsberg, FW, Dye, JM, Qiu, X, M Aman, J
JournalNat Commun
Volume10
Issue1
Pagination105
Date Published2019 01 10
ISSN2041-1723
Abstract

The 2013-2016 Ebola virus (EBOV) disease epidemic demonstrated the grave consequences of filovirus epidemics in the absence of effective therapeutics. Besides EBOV, two additional ebolaviruses, Sudan (SUDV) and Bundibugyo (BDBV) viruses, as well as multiple variants of Marburg virus (MARV), have also caused high fatality epidemics. Current experimental EBOV monoclonal antibodies (mAbs) are ineffective against SUDV, BDBV, or MARV. Here, we report that a cocktail of two broadly neutralizing ebolavirus mAbs, FVM04 and CA45, protects nonhuman primates (NHPs) against EBOV and SUDV infection when delivered four days post infection. This cocktail when supplemented by the anti-MARV mAb MR191 exhibited 100% efficacy in MARV-infected NHPs. These findings provide a solid foundation for clinical development of broadly protective immunotherapeutics for use in future filovirus epidemics.

DOI10.1038/s41467-018-08040-w
Alternate JournalNat Commun
PubMed ID30631063
PubMed Central IDPMC6328579
Grant ListR01 AI126587 / AI / NIAID NIH HHS / United States
R43 AI124765 / AI / NIAID NIH HHS / United States