Debajit Dey (he/him)

Hasan Group

Contact

Email: ddey@som.umaryland.edu

Call: (240) 314-6205

Education

  • Ph.D., Biological Sciences, Indian Institute of Technology (IIT) Delhi, India, 2020
  • M.E., Biotechnology, Birla Institute of Technology and Science (BITS) Pilani, India, 2013
  • B.Tech., Biotechnology, West Bengal University of Technology (WBUT), India, 2010

Profile

My research interest is primarily focused on understanding how viruses and viral proteins interact with their host at the molecular level. Viruses have evolved an impressive array of techniques to manipulate and exploit host cell processes to their advantage. Extensive biochemical, cellular and structural characterization of such interactions is key for two major reasons: (i) elucidation of virus life cycle in greater detail in context of the virus-host interactome and (ii) identification of novel therapeutic targets. My previous research has focused on RNA viruses including chikungunya virus (CHIKV), hepatitis A virus (HAV), flock house virus (FHV, insect virus) and SARS CoV-2 wherein except FHV all are known human pathogens. As a postdoc in the Hasan lab, my current research is focused on understanding the role of cellular trafficking pathways in the assembly of SARS-2.

 

Publications
2023
Structure and energetics guide dynamic behaviour in a T = 3 icosahedral virus capsid.
A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs.
Strategies for rapid production of crystallization quality coatomer WD40 domains.
Structural investigations of the palmitoylated F13 envelope protein of Mpox virus.
2022
Interactions of angiotensin-converting enzyme-2 (ACE2) and SARS-CoV-2 spike receptor-binding domain (RBD): a structural perspective.
Unravelling viral dynamics through molecular dynamics simulations - A brief overview.
An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking.
2021
The Structural Biology of Eastern Equine Encephalitis Virus, an Emerging Viral Threat.
Structural and biochemical insights into flavivirus proteins.
Computational Insight Into the Mechanism of SARS-CoV-2 Membrane Fusion.
2020
In silico identification of Tretinoin as a SARS-CoV-2 envelope (E) protein ion channel inhibitor.
2019
Hydrophobicity and oligomerization are essential parameters for membrane penetration activity of the VP4 peptide from Hepatitis A Virus (HAV).
The effect of amantadine on an ion channel protein from Chikungunya virus.
2017
Breach: Host Membrane Penetration and Entry by Nonenveloped Viruses.
2016
Inhibitor-Based Therapeutics for Treatment of Viral Hepatitis.
Non-Enveloped Virus Entry: Structural Determinants and Mechanism of Functioning of a Viral Lytic Peptide.
2015
The C-terminal region of the non-structural protein 2B from Hepatitis A Virus demonstrates lipid-specific viroporin-like activity.