Biomolecular Engineering

Biomolecular engineering reflects the much-needed interface between biology and engineering. Biomolecular Engineering at IBBR leverages departmental faculty and expertise at the University of Maryland, applying engineering principles to the manipulation of biological molecules and proteins.

IBBR researchers work together to effectively integrate molecular-level events into an understanding of complex biological systems, and to create the next generation of tools necessary for rapid, accurate and cost-effective analysis of biomolecules. Biofabrication – the use of biomolecules and biological materials and mechanisms for construction – offers the opportunity to span these disciplines by providing convergent and synergistic approaches for building biological device interfaces.

Projects and Spotlights

Polyphosphazene Microneedles for Intradermal Vaccination

Skin is an attractive organ for administration of vaccines since it constitutes an anatomic barrier, defending the body against external pathogens. Since the skin is home to a larger population of...Read More

Designing New Biomolecular-Friendly Smart Materials

Safe, reliable, flexible methods of drug delivery IBBR advances a novel approach to the development of drug delivery carriers utilizing the power of synthetic...Read More

Innovo BioPolymers

Bridging academic research and commercial activityCommercializing polyphosphazene technology IBBR scientists are working with a proprietary technology based on polyphosphazene...Read More

Hepatitis C Virus Vaccine

Up to 170 million people worldwide are chronically infected with Hepatitis C Virus (HCV), with many at significant risk for cirrhosis, liver failure and hepatocellular carcinoma.  The World Health...Read More

Mobilizing Biomolecular Therapeutics in the Body

The design of drug targeting strategies to enable delivery of therapeutic agents to areas of the body requiring intervention is an active research field. Therapeutic targets are often confined to...Read More

Nano-guided Cell Networks as Conveyors of Molecular Information

Molecular communications open new doors connecting microelectronic devices and biological systemsIBBR Bioengineering faculty and collaborators are exploiting synthetic biology to enable “cell-...Read More

Understanding Oxidative Stress through Reverse Engineering

There is growing evidence that oxidative stress plays a role in human maladies that range from bowel diseases to mental health disorders.  However, the current understanding of oxidative stress is...Read More

IBBR HIV-1 Vaccine Development

An effective HIV-1 vaccine designed to prevent acquisition of infection will require elicitation of effective antibody responses to the envelope glycoprotein (Env) that mediates virus entry.  Env-...Read More

Vaccines aimed at Filoviruses

Infection of humans by filoviruses has been shown to result in mortality rates that can exceed 85%. Of the filovirus outbreaks that have been documented thus far, the species Zaire (ZEBOV), Sudan (...Read More

Research Faculty