Biomolecular Therapeutics

The goal of Biomolecular Therapeutics is to develop drugs that specifically target medically-important biological macromolecules in a disease state, thereby altering their action in a manner that achieves a therapeutic benefit. Biomolecular Therapeutics encompasses a diverse array of disease states and targets and therefore impacts most of the research focus areas pursued at the IBBR and other research centers throughout the University System of Maryland (USM).

The CBT is made up of seven sections which provides a complete set of skills for developing therapeutics

A major driver in Biomolecular Therapeutics is the Center for Biomolecular Therapeutics (CBT). The CBT is a USM-wide initiative, facilitated by a partnership between the University of Maryland-Baltimore and the University of Maryland at College Park at the IBBR, which is dedicated to the development of commercial diagnostic and therapeutic products that benefit human and environmental health. The CBT has investigators with the full range of scientific expertise required for the development of therapeutics. In particular, the CBT comprises seven sections: Genomics and Bioinformatics, Medicinal Chemistry, Target Validation and Screening, In vivo Biology and Drug Testing, Protein Production and Biophysics, Structural Biology, and Computer-aided Drug Design. The CBT leverages this expertise to collaborate with USM investigators and industry partners to investigate targets of both medical and commercial importance. Through this partnership, the CBT is developing a “discovery-to-commercialization” pipeline that couples state-of-the art science with business and regulatory expertise to accelerate the translation of important basic science discoveries to the marketplace.

Projects and Spotlights

Designing New Biomolecular-Friendly Smart Materials

Safe, reliable, flexible methods of drug delivery IBBR advances a novel approach to the development of drug delivery carriers utilizing the power of synthetic...Read More

Type 2 Diabetes

Diabetes is a metabolic disorder that is currently affecting as many as 350 million people worldwide.  Its occurrence is on the rise, correlates with increase in obesity and is estimated to shorten...Read More

Cancer Metastasis

Figure 1. Ca2+ dependent NMIIA-S100A4 interaction. (A) The structure of apo, CA2+, and NMIIA1893-1928 bound S100A4 have been solved showing a hyrdrophobic cleft in S100A4 revealed upon Ca2+ binding...Read More

Alzheimer's Disease

Alzheimer's disease (AD) is a global public health threat, and will likely surpass cancer as the leading cause of death in the 21st century. The number of individuals afflicted with this...Read More

Critical Assessment of Genome Interpretation

Identifying and analyzing genetic variants in human diseaseComputational analysis identified a genetic variant in Macrophage Stimulating Protein (MSP) as likely involved in contributing to risk of...Read More

Targeting S100 proteins in melanoma

Every year in the United States alone, nearly six hundred thousand people die of cancer.  This devastating disease comes in many different forms.  Almost eighty thousand people in the US are...Read More

Research Faculty