Host-Pathogen Interactions

Infectious diseases continue to pose significant risks to human, animal and plant health.  A better understanding of these threats – and the mechanisms that host cells mount to fend off the infections – is key to the diagnosing, treating and preventing the spread of disease.

IBBR uses reverse and forward genetic approaches and DNA transformation technologies with model and pathogenic organisms to understand and manipulate gene regulation and function in the context of disease. This research will lead to a better understanding of the biological, biochemical and biophysical processes of host-pathogen interactions.

Chestnut blight fungus

IBBR core researchers associated with Host Pathogen Interactions utilize major infrastructure that includes:

  • Insect Transformation Facility
  • Mass spectrometry
  • Confocal microscopy
  • Illumina sequencing core

Projects and Spotlights

Insect Transformation Facility

A Platform for Insect Genetic Modification The Institute for Bioscience and Biotechnology’s Insect Transformation Facility (ITF) leverages broad and deep knowledge and expertise...Read More

Characterizing and Exploiting “Missile”-Like Defense in Plants

We identified a novel type of plant resistance proteins that fight against fungal invasion right at the host-pathogen interface. Pathogenic fungi cause huge crop losses worldwide....Read More

Enzybiotics – A New Weapon against Multi-Drug Resistant Bacteria

Not only do enzybiotics act on contact, but they are highly species specific, meaning they can target pathogenic organisms yet are harmless to commensal organisms (i.e. good bacteria), a benefit not...Read More

Research Faculty