IBBR Seminar Series
For almost a century, it has been recognized that influenza virus infections promote the development of a lethal form of bacterial disease. For example, during the 1918 influenza pandemic, S. pneumoniae was recovered in ~95% of all fatal cases. Herein, we aim to study the complex and synergistic interactions that occur during co- and secondary bacterial infections to influenza. Using immunological, bacterial pathogenesis and quantitative proteomic approaches we have discovered that primary influenza infection potentiates the cytotoxic activity of S.
In a eukaryotic cell, most membrane-bound organelles over their life time transition through multiple morphological states driven by functional cues. In addition to endogenous events, this morphological flux is also induced by various diseases and pathogenic invasions. Despite these recurrent examples of the nexus between form and function of organelles a visual understanding of these morphofunctional transitions is rudimentary.
Because of sessile nature, plants have to cope with various adverse environmental conditions collectively referred as abiotic stresses, including drought, temperature extremes, and soil salinity. Improvements in plant abiotic stress resistance through genetic engineering have limited success due to the lack of comprehensive understanding of the molecular mechanisms of plant abiotic stress responses. My laboratory uses a combination of forward and reverse genetic approaches to identify genes essential for plant abiotic stress responses in several model plant species including Arabidopsis,
Proteins, and their three-dimensional structures, are central to many aspects of biotechnology and medicine. However, our view of protein structure is biased by our crystallographic technology -- in which we study protein structures in crystal lattices.