IBBR Seminar Series
Summary: The protein folding systems in the hyperthermophilic and psychrophilic Archaea are simplified model systems of the chaperones of Eukarya. Their properties have been adapted for the creation of heat stable vaccines with potential impact on diseases in the developing world.
Summary: Antibodies make up the largest, growing segment of protein therapeutics in the pharmaceutical and biotechnology industries. The development or engineering of therapeutic antibodies is based on our knowledge of antibody structure and requires sophisticated methods that continue to evolve. These methods include antibody humanization, antigen-affinity optimization, Fc engineering for modulating effector function and extending half-life, and engineering for improved stability and biophysical properties.