IBBR Seminar Series
Kyle Anderson: "Dynamics of IgG1 glycoforms and interaction with FcγR1"
Mark Lowenthal: "Development of NIST SRM 3655 – Glycans in Solution"
120 502 5830
Multiple lipoproteins are known to be causal risk factors for cardiovascular disease (CVD). While LDL cholesterol (LDL-C) has been causally linked to CVD risk, the link of HDL-C, the “good cholesterol”, to CVD is much more complicated and the HDL-C as a metric of HDL’s antiatherogenic properties has been put in question both by genetics studies and by failure of pharmacologic elevation of HDL-C to lower CVD risk. We’ve developed a novel measurement of HDL that directly measures concentration of HDL particles (including individual subspecies) as opposed to the HDL cholesterol content.
Although much is known about lipoprotein biology, particularly low-density lipoproteins (LDL), because of their strong associations with cardiovascular disease, many questions about the less well-understood high density lipoproteins (HDL) remain unanswered. Lipoproteins are lipid nanoparticles that range in size from the smallest HDL particles which are 5nm in diameter, to the largest intestinally-derived chylomicron particles which can be as large as 1000nm in diameter.
DNA replication and repair are essential biological processes needed for the survival of all organisms across all domains of life. Interestingly, a variety of archaeal species thrive in extreme environments, including high temperature, high salt, and low pH, and must maintain their genome under such extremes. In this talk I will present two technologies developed and utilized by our lab at New England Biolabs to study DNA replication and repair in hyperthermophilic Archaea.
Complex Glycans in Health and Disease
Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602 (USA) and Utrecht University, Chemical Biology and Drug Discovery, Universiteitsweg 99, 3584 CG Utrecht, the Netherlands
Steve Semancik: "Basic and Applied Aspects of Developing Biomedical Sensors"
Sarah Riman: “A Comparative Study of Two Different LR Systems for Discrimination Performance and LR Calculations Using the PROVEDIt Dataset”
"Accelerated Adoption via Adaptation and Innovation: mAbs, CGT and Beyond"
“DNA repair-based drug developments in cancer therapy”