IBBR Internal Seminar

Molecular Mechanism Underlying the Action of Influenza A Virus Fusion Inhibitor MBX2546

Influenza viruses are a major public health threat worldwide, and options for antiviral therapy are becoming limited by the emergence of drug-resistant virus strains. The influenza virus glycoprotein hemagglutinin (HA) plays critical roles in the early stage of virus infection making it a potential target for the development of anti-influenza drugs. We have identified a novel influenza virus inhibitor, MBX2546, with sulfonamide scaffolds that specifically inhibit HA-mediated viral entry.