CBT Seminar

In allostery, a signal from one site in a protein is transmitted to a second site to alter its function. Due to its ubiquity in biology and the potential for its exploitation in drug and protein design, the molecular basis of allosteric communication continues to be a subject of intense research. Biotin protein ligases are essential enzymes for survival in all organisms. In bacteria the Class 1 or monofunctional ligases only catalyze post-translational biotin addition while the Class 2 proteins also function as transcription repressors.