Special Seminar

Dissertation defense: INVESTIGATION INTO THE ROLE OF UVR8 IN BALANCING GROWTH AND ACCLIMATION TO UV-B RADIATION IN NATURAL AND TRANSGENIC POPULUS VARIANTS

Research on woody plants offers promise for the development of next-generation biofuel feedstocks with reduced lignin recalcitrance and enhanced saccharification for ethanol production. Natural variants of Populus trichocarpa with diverse lignin content and saccharification differences, and transgenic Populus deltoides constructed for reduced lignin levels for improved cellulose extraction, offer clues to enhance biofuel production but with a tradeoff to overall fitness and biomass.

cryoEM candidate seminar: A Song of Ice and Fire: Cryo-EM Interrogation of the heat Shock Protein 90 Chaperone Machinery

Heat Shock Protein 90 (Hsp90) is a ubiquitous molecular chaperone that facilitates the folding and maturation of hundreds of “client” proteins, highly enriched for signaling and regulatory processes. Despite the functional importance, how Hsp90 mediates client protein maturation and how this process is regulated by co-chaperones are largely unknown. In my presentation, I will share three stories that address these questions.

UMCP Biophysics Seminar: The Genotype-Phenotype Landscape of an Allosteric Protein

Allostery is a fundamental biophysical mechanism that underlies cellular sensing, signaling, and metabolism. Yet, because of its structurally distributed nature, a quantitative understanding of allosteric genotype-phenotype relationships remains elusive. To provide the large-scale data needed to inform predictive models of allosteric function, we have developed a method to quantitatively measure the dose-response curves and matching DNA sequences for every variant in a large library of allosteric sensor proteins.