So many ways of getting in the way: diversity in the molecular architecture of superantigen-dependent T-cell signaling complexes.

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TitleSo many ways of getting in the way: diversity in the molecular architecture of superantigen-dependent T-cell signaling complexes.
Publication TypeJournal Article
Year of Publication2002
AuthorsSundberg, EJ, Li, Y, Mariuzza, RA
JournalCurr Opin Immunol
Volume14
Issue1
Pagination36-44
Date Published2002 Feb
ISSN0952-7915
KeywordsAlleles, Animals, Humans, Major Histocompatibility Complex, Models, Molecular, Protein Binding, Protein Conformation, Receptors, Antigen, T-Cell, Signal Transduction, Superantigens, T-Lymphocytes
Abstract

Superantigens (SAGs) elicit massive T-cell proliferation through simultaneous interaction with MHC and TCR molecules. SAGs have been implicated in toxic shock syndrome and food poisoning, and they may also play a pathogenic role in autoimmune diseases. The best-characterized group of SAGs are the pyrogenic bacterial SAGs, which utilize a high degree of genetic variation on a common structural scaffold to achieve a wide range of MHC-binding and T-cell-stimulating effects while assisting pathogen evasion of the adaptive immune response. Several new structures of SAG-MHC and SAG-TCR complexes have significantly increased understanding of the molecular bases for high-affinity peptide/MHC binding by SAGs and for TCR Vbeta domain specificity of SAGs. Using the currently available SAG-MHC and SAG-TCR complex structures, models of various trimolecular MHC-SAG-TCR complexes may be constructed that reveal wide diversity in the architecture of SAG-dependent T-cell signaling complexes, which nevertheless may result in similar signaling outcomes.

Alternate JournalCurr. Opin. Immunol.
PubMed ID11790531