News Stories
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Dr. S. Saif Hasan Promoted to Associate Professor with Tenure
We are pleased to congratulate IBBR Fellow Dr. S. Saif Hasan on his promotion to Associate Professor with tenure in the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine. Since joining IBBR in 2019, Dr. Hasan has established an internationally recognized research program focused...
IBBR’s Wright Makambi Awarded NRC Postdoctoral Fellowship
IBBR proudly congratulates Wright Makambi on receiving a National Research Council (NRC) postdoctoral fellowship. The NRC award provides competitive postdoctoral opportunities nationwide, allowing fellows to pursue advanced research and provides access to valuable and specialized facilities. This prestigious award recognizes Makambi’s research achievements and will provide support for his continued...
Dr. John Moult Honored with 2027 ASBMB DeLano Award for Computational Biosciences
We are proud to congratulate Dr. John Moult on receiving the 2027 American Society for Biochemistry and Molecular Biology (ASBMB) DeLano Award for Computational Biosciences. This prestigious award recognizes a scientist who develops or applies innovative and accessible computational approaches to advance research in the life sciences at the molecular...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
Seminar: Richard Kuhn, Purdue
AT NIST | BMD Staff Seminar: Y. Liu (.04), M. Cleveland (.06)
NIST Group Meeting; Shayna Hilburg
Recent Publications
Discovery of YA8026, an optimized human constitutive androstane receptor activator from a novel ML241-derived scaffold.
The human constitutive androstane receptor (hCAR) regulates drug metabolism and represents a promising target for enhancing cyclophosphamide (CPA) bioactivation through CYP2B6 induction. However,...
DC+: A web server for the analysis of residual dipolar couplings.
A server-based program, DC+, is presented for analysis of residual dipolar couplings (RDCs) and residual chemical shift anisotropy (RCSA) in proteins and nucleic acids. The program aims to meet...
Automated pharmacophore hypothesis generator for SILCS-Pharm: ph4gen.
Here we present ph4gen, a tool for the automated generation of pharmacophore hypotheses developed for use with the site identification by ligand competitive saturation (SILCS) technology. It...
Boosting genome editing in perennial plants by CRISPR-Combo mediated morphogenic gene activation.
A major bottleneck in genome editing of many perennial plants is their recalcitrance to transformation and regeneration. To boost genome editing in such perennial crops, transcriptional...
Shape-shifting proteins and the subtlety in their form and function.
Shape-shifting proteins include intrinsically disordered proteins (IDPs) and fold-switching, or metamorphic proteins. They make up a significant fraction of the "dark proteome" in the protein...