IBBR Postdoc Julia Greenfield Wins Outstanding Poster Award
On May 3, 3023, Dr. Julia Greenfield, a NIST postdoctoral research associate at IBBR was awarded “Outstanding Poster” for her presentation entitled, “Characterization of freeze-induced transient high-molecular-weight (HMW) species in BiTE solution” at the NIST Sigma Xi Early Career Poster Presentation. Her poster described results from collaborative research aimed at...
Collaborative Research Leads to $2.7M from the National Science Foundation to Elucidate Non-Host Resistance (NHR) Mechanisms for Improving Crop Resistance Against Aggressive Pathogens
Globally, ~15% of crop losses are caused by various aggressive pathogens especially fungi, highlighting the importance of crop protection against pathogens. In nature, most plants are resistant to most potential pathogens because of a phenomenon, namely nonhost resistance (NHR). A prime example of NHR is rice’s complete immunity to rust...
Adit Alreja Receives Dean’s Outstanding Teaching Assistant Award
Adit Alreja, a Ph.D.candidate in Daniel Nelson’s lab at IBBR was recently awarded the Dean’s Outstanding Teaching Assistant Award, an award that is nominated by students. This award is presented to an undergraduate or a graduate student who acts as a teaching assistant for a course being taught by the...
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Seminar: "Biomanufacturing and Quality Control for the Next New Therapeutic Modality: Live Microbes"
Tuesday, May 30, 2023 - 11:00am
Tuesday, May 30, 2023 - 12:00pm
Wednesday, May 31, 2023 - 11:00am
Fluorine-Functionalized Polyphosphazene Immunoadjuvant: Synthesis, Solution Behavior and In Vivo Potency.
The inclusion of fluorine motifs in drugs and drug delivery systems is an established tool for modulating their biological potency. Fluorination can improve drug specificity or boost the vehicle's...
Transglutaminase 2 binds to the CD44v6 cytoplasmic domain to stimulate CD44v6/ERK1/2 signaling and maintain an aggressive cancer phenotype.
Transglutaminase 2 (TG2) is a key cancer cell survival protein in many cancer types. As such, efforts are underway to characterize the mechanism of TG2 action. In the present study we report that...
High performance anion exchange chromatography purification of probiotic bacterial extracellular vesicles enhances purity and anti-inflammatory efficacy.
Bacterial extracellular vesicles (BEVs), including outer membrane vesicles (OMVs), have emerged as a promising new class of vaccines and therapeutics to treat cancer and inflammatory diseases,...
Rootstock-induced scion resistance against tobacco mosaic virus is associated with the induction of defence-related transcripts and graft-transmissible mRNAs.
Grafting is a common horticultural practice used to confer desirable traits between rootstock and scion, including disease resistance. To investigate graft-conferred resistance against viral...