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USG Bionetworking Summit 11/13
Please join us on Thursday, November 13th from 6-8pm for our bioscience-focused networking event series designed to highlight the area’s unique life science ecosystem and to promote interactions between its diverse stakeholders. Sponsored and organized by the University of Maryland, Baltimore County (UMBC), the Institute for Bioscience and Biotechnology Research...
Rui Yin, a scientist at Absci and former student in the Pierce Lab at IBBR, is using AI to unlock the cures for previously incurable diseases.
Rui Yin (Ph.D. ’24, biological sciences) is on a mission to fight human disease. In her research at Absci, a next-generation drug development company, the data-processing power of artificial intelligence (AI) is her most valuable tool.
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New Term ‘Translon’ Proposed to Standardize Genetic Technology
A recent publication in Nature Methods introduced a new term, ‘translon,’ to denote any region of genetic code that is translated. The article, entitled "Translon: a single term for translated regions,” was co-authored by an international team of researchers including Dr. Jonathan Dinman, Director of IBBR.
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
Seminar: "A RECEPTOR WITH A SWEET TOOTH"
Jon Fay
UMB
Monday, November 3, 2025 - 11:00am
BMD Staff Seminar M. Judge/ Y. Simon, .03/.04
Tuesday, November 4, 2025 - 11:00am
NIST Group Meeting: Svetlana Ikonomova
Wednesday, November 5, 2025 - 11:00am
Recent Publications
Modeling Alternative Conformational States in CASP16.
The CASP16 Ensemble Prediction experiment assessed advances in methods for modeling proteins, nucleic acids, and their complexes in multiple conformational states. Targets included systems with...
Polyphosphazene-Mediated Assembly of TLR4 and TLR7/8 Agonists Enables a Potent Nano-Adjuvant Delivery System for Hepatitis C Virus Vaccine Antigens.
Background: The quest for well-defined immunoadjuvants remains one of the highest priorities for the successful development of effective vaccines. Combination adjuvants, which are designed to...
Kinetic investigation of calcium-induced Sorcin aggregation by stopped-flow light scattering.
Sorcin, a penta-EF hand calcium-binding protein, is implicated in multidrug resistance (MDR) in various cancers and has roles in neurodegenerative diseases. It regulates cellular calcium...
Drude Polarizable Force Field for Phosphorylated Polypeptides and Proteins.
Phosphorylation is a ubiquitous post-translational modification used across all domains of life to regulate protein stability, folding, subcellular localization, function, and activity. The most...
Transgene-free genome editing in citrus and poplar trees using positive and negative selection markers.
Transgene-free genome editing of the gene of interest in citrus and poplar has been achieved by co-editing the ALS gene via transient transgene expression of an efficient cytosine base editor....