IBBR advances ground-breaking research, technology development and standards with a focus on:
- Basic science, measurement technology and standards that advance discovery, development, and manufacture of complex therapeutic drugs and vaccines.
- Basic science, measurement technology and data science that advance engineering of biological molecules and biomolecular systems relevant to pharmaceutical development and biotechnology applications.
T cell receptor-p53-HLA-A2 complex (Wu, D., Gallagher, D.T., Gowthaman, R., Pierce, B.G., Mariuzza, R.A.)
Dr. Edvin Pozharskiy (IBBR Fellow) collects Cryo-EM data
IBBR research involves advancing state-of-the-art methods and measurements, including:
- Approaches for determination of the structure and dynamics of biological molecules at atomic resolution, including cryo-electron microscopy (cryo-EM), nuclear magnetic resonance (NMR), x-ray crystallography (XRD), small angle neutron and x-ray scattering (SANS/SAXS) and HDX-mass spectrometry (MS)).
- Quantitative analysis of biological molecules and biomolecular complexes and mixtures using advanced bioanalytical tools
- Computational modeling, AI, machine learning and deep learning in applications including data & image analysis, and modeling/prediction of biomolecular structure, stability, and biomolecular interactions, with a focus on those involving therapeutic intervention.
IBBR strives to bring together IBBR Researchers to meet certain strategic objectives including, but not limited to:
- Fostering interdisciplinary approaches and building scientific expertise that will drive measurement innovation and facilitate the translation of basic scientific discoveries to the development and manufacture of therapeutics and vaccines.
- Building external collaborations with industry, academic and federal laboratories, as well as state agencies and technology development organizations, to support basic science and translational of biomedical, biotechnology and measurement solutions.
- Providing specialized training and mentoring opportunities to educate the next generation of biotechnology, bioscience, and biomedical researchers.
Dr. Daniel Nelson (IBBR Fellow) alongside postdoc associate Dr. Sara Linden