Differential inhibition of vesicular stomatitis virus polypeptide synthesis by hypertonic initiation block.

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TitleDifferential inhibition of vesicular stomatitis virus polypeptide synthesis by hypertonic initiation block.
Publication TypeJournal Article
Year of Publication1975
AuthorsNuss, DL, Koch, G
JournalJ Virol
Volume17
Issue1
Pagination283-6
Date Published1975 Jan
ISSN0022-538X
KeywordsAnimals, Culture Media, Culture Techniques, Glycoproteins, Mice, Peptide Biosynthesis, Peptide Chain Initiation, Translational, Plasmacytoma, Polyribosomes, Saline Solution, Hypertonic, Sodium Chloride, Vesicular stomatitis Indiana virus, Viral Proteins
Abstract

Synthesis of the vesicular stomatitis virus membrane matrix protein and the glycoprotein is inhibited to a greater extent than the synthesis of the nucleocapsid protein, the nonstructural protein, and the large protein when the rate of peptide chain initiation is reduced by exposure of vesicular stomatitis virus-infected cells to hypertonic medium. It is concluded that the relative sensitivity of individual viral polypeptide synthesis to hypertonic initiation block is independent of the site of synthesis, i.e., whether on membrane-associated or free polyribosomes.

Alternate JournalJ. Virol.
PubMed ID173890
PubMed Central IDPMC515413