Maintenance of HIV-Specific Memory B-Cell Responses in Elite Controllers Despite Low Viral Burden.

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TitleMaintenance of HIV-Specific Memory B-Cell Responses in Elite Controllers Despite Low Viral Burden.
Publication TypeJournal Article
Year of Publication2016
AuthorsBuckner, CM, Kardava, L, Zhang, X, Gittens, K, J Justement, S, Kovacs, C, McDermott, AB, Li, Y, Sajadi, MM, Chun, T-W, Fauci, AS, Moir, S
JournalJ Infect Dis
Date Published2016 Apr 27
ISSN1537-6613
Abstract

HIV-specific B-cell responses in infected individuals are maintained by active HIV replication. Suppression of viremia by antiretroviral therapy (ART) leads to quantitative and qualitative changes that remain unclear. Accordingly, B-cell responses were investigated in elite controllers (EC) who maintain undetectable HIV levels without ART and individuals whose viremia was suppressed by ART. Despite a higher HIV burden in the ART versus EC group, frequencies of HIV-specific B cells were higher in the EC versus ART group. However, initiation of ART in several EC was associated with reduced frequencies of HIV-specific B cells, suggesting that responses are at least in part sustained by HIV replication. Furthermore, B-cell responses to tetanus but not influenza were lower in the ART versus EC group. Thus, the superior HIV-specific humoral response in EC versus ART-treated individuals is likely due to a more intact humoral immune response in EC and/or distinct responses to residual HIV replication.

DOI10.1093/infdis/jiw163
Alternate JournalJ. Infect. Dis.
PubMed ID27122593