Alexander Andrianov

Research Professor

Andrianov Group

Contact

Email: aandrianov@umd.edu

Call: (240) 314-6456

Education

  • Postdoctoral Research, Chemical Engineering, Massachusetts Institute of Technology (MIT), 1991-1993
  • Ph.D., Polymer Science, Moscow State University, 1985
  • B.S., Chemistry, Moscow State University, 1980

Profile

Dr. Alexander Andrianov is a leader in the field of polyphosphazenes with a long-standing interest in applications of polymers for drug delivery systems and biomaterials. He has been involved in all aspects of technology development and commercialization, including product advancement from the research laboratory to manufacturing and clinical trials. Dr. Andrianov has served in various executive and managerial roles at a number of biotechnology companies focusing on drug delivery technologies and biomaterials, and he has worked as a biotechnology consultant to industrial, academic, and global health organizations.

CURRENT RESEARCH

The Andrianov lab uses the polyphosphazene technology platform to develop novel materials for life sciences applications and studies interactions of these macromolecules with biologically important targets. Current projects include the development of potent macromolecular immunomodulators and vaccine delivery vehicles, biodegradable nanoparticulate drug delivery carriers with built-in ‘smart’ intracellular delivery functions, non-covalent PEGylation systems for extending protein half-life, and novel polyelectrolytes for aqueous layer-by-layer assembly of biocompatible, self-healing, fluorinated coatings.

The lab integrates expertise in rational design, controlled synthesis and scaled-up production of these macromolecules, as well as precise formulation and nanofabrication methods. It is equipped with state-of-the-art equipment and expertise for screening macromolecules for critical parameters such as biocompatibility and interactions with important protein targets.

Polyphosphazenes
Polyphosphazenes for vaccine and drug delivery
Polyphosphazene biomaterials

    

Publications
2022
Hierarchically Structured, All-Aqueous-Coated Hydrophobic Surfaces with pH-Selective Droplet Transfer Capability.
Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate.
Cationic Fluoropolyphosphazenes: Synthesis and Assembly with Heparin as a Pathway to Hemocompatible Nanocoatings.
2021
Nano-Assembly of Quisinostat and Biodegradable Macromolecular Carrier Results in Supramolecular Complexes with Slow-Release Capabilities.
Immunopotentiating and Delivery Systems for HCV Vaccines.
Supramolecular assembly of Toll-like receptor 7/8 agonist into multimeric water-soluble constructs enables superior immune stimulation in vitro and in vivo.
Intracellular Delivery of Active Proteins by Polyphosphazene Polymers.
Improvement of RG1-VLP vaccine performance in BALB/c mice by substitution of alhydrogel with the next generation polyphosphazene adjuvant PCEP.
Next generation polyphosphazene immunoadjuvant: Synthesis, self-assembly and in vivo potency with human papillomavirus VLPs-based vaccine.
Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer.
2020
Polyphosphazenes enable durable, hemocompatible, highly efficient antibacterial coatings.
Polyphosphazene immunoadjuvants: Historical perspective and recent advances.
Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.
In Vivo and In Vitro Potency of Polyphosphazene Immunoadjuvants with Hepatitis C Virus Antigen and the Role of Their Supramolecular Assembly.
2019
Protein-loaded soluble and nanoparticulate formulations of ionic polyphosphazenes and their interactions on molecular and cellular levels.
New Family of Water-Soluble Sulfo-Fluoro Polyphosphazenes and Their Assembly within Hemocompatible Nanocoatings.
2018
Hydrolytically Degradable PEGylated Polyelectrolyte Nanocomplexes for Protein Delivery.
Biocompatible Nanocoatings of Fluorinated Polyphosphazenes through Aqueous Assembly.
Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity.
2017
PCPP-Adjuvanted Respiratory Syncytial Virus (RSV) sF Subunit Vaccine: Self-Assembled Supramolecular Complexes Enable Enhanced Immunogenicity and Protection.