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Early Career Symposium at IBBR (ECSI) 2022: Unmasking the Structure-Function Relationship of Biomolecules in Disease and Therapeutics
The Institute for Bioscience and Biotechnology Research (IBBR) invites you to participate in the first Early Career Symposium at IBBR (ECSI) 2022: Unmasking the Structure-Function Relationship of Biomolecules in Disease and Therapeutics on Thursday, September 15, 2022 from 8:30am-5:00pm at our facility in Rockville, Maryland. We aim to provide a...
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T-Cell Based Vaccines May Be Key to Long-Term Coronavirus Immunity
The emergence of multiple variants of SARS-CoV-2 has brought major challenges to the effectiveness in vaccine development. Researchers concentrating their efforts on mutations of the virus, including Roy Mariuzza, IBBR Fellow and Professor, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park have relied heavily on the...
Anderson and Hudgens Develop New Instrument for Higher Precision Measurement of Protein Dynamics
NIST-IBBR scientists Kyle Anderson and Jeffrey Hudgens recently reported* the design and performance metrics of a new, ‘sub-zero’ dual-enzyme hydrogen deuterium exchange mass spectrometry (HDX-MS) instrument. The new HDX-MS instrument dramatically improves the precision by which protein dynamics can be measured and could enable more robust application of the technique...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
BMD Seminar: "Getting the most from touch DNA" by Dr. Adrian Linacre
Tuesday, August 16, 2022 - 11:00am
Friday, August 26, 2022 - 11:00am
Ronald Rock
The University of Chicago
Monday, October 3, 2022 - 11:00am
Recent Publications
Associations Between Sleep Health and Amygdala Reactivity to Negative Facial Expressions in the UK Biobank Cohort.
BACKGROUND
Sleep health (SH) is considered a key determinant of human physiological and psychological well-being. In line with this, previous studies have found that poor sleep is associated with...
Spatial requirements for ITAM signaling in an intracellular natural killer cell model membrane.
FcγRIIIa-FcεRIγ complexes, upon stimulation by antibodies, cluster to initiate intracellular signaling and activate natural killer (NK) cells. Intracellular signaling involves Lck...
Preserving the Integrity of Empirical Force Fields.
Generalized force fields (FFs) act as extensions to biomolecular FFs to provide a wide coverage of organic molecules. However, their precise application to an arbitrary molecule presents a...
SILCS-RNA: Toward a Structure-Based Drug Design Approach for Targeting RNAs with Small Molecules.
RNA molecules can act as potential drug targets in different diseases, as their dysregulated expression or misfolding can alter various cellular processes. Noncoding RNAs account for ∼70% of the...
Altered blood-brain barrier transport of nanotherapeutics in lysosomal storage diseases.
Treatment of neurological lysosomal storage disorders (LSDs) are limited because of impermeability of the blood-brain barrier (BBB) to macromolecules. Nanoformulations targeting BBB transcytosis...