Novel shape-shifting proteins may provide deeper insights into the folding code
Recently, there have been significant advances into understanding the protein folding code - that is, how the amino acid sequence of a protein relates to its three-dimensional structure. However, it is known that some naturally occurring proteins can adopt two very different structural states depending on their environment. Such “metamorphic”...
The Andrianov Lab Receives Sub-Award to Aid in the Development of a Dissolvable Microneedle Patch Vaccine against the Dangerous Nipah virus and Hendra virus
The University of Maryland - Institute for Bioscience and Biotechnology Research (IBBR) Fellow, Dr. Alexander Andrianov received a two-year $290,000 sub award from the Henry M. Jackson Foundation for the Advancement of Military Medicine on behalf of Uniformed Services University (USU) in Bethesda, MD, as part of a multi-million dollar...
IBBR Co-Director David Weber Selected as MPower Professor
Dr. David Weber, Co-Director of the Institute for Bioscience and Biotechnology Research (IBBR), Director of the Center for Biomolecular Therapeutics (CBT), Director of the Maryland Center for Advanced Molecular Analysis (M-CAMA), and a Professor in the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine,...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
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IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
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Recent Publications
Wheat Pore-forming toxin-like protein confers broad-spectrum resistance to fungal pathogens in Arabidopsis.
Fusarium head blight (FHB), caused by the hemibiotrophic fungus Fusarium graminearum, is one of the major threats to global wheat productivity. A wheat Pore-Forming Toxin-like (PFT) protein was...
Cell-Like Capsules with "Smart" Compartments.
Eukaryotic cells have inner compartments (organelles), each with distinct properties and functions. One mimic of this architecture, based on biopolymers, is the multicompartment capsule (MCC)....
Backbone NMR assignment of the yeast expressed Fab fragment of the NISTmAb reference antibody.
The monoclonal antibody (mAb) protein class has become a primary therapeutic platform for the production of new life saving drug products. MAbs are comprised of two domains: the antigen-binding...
Targeted Degradation of Androgen Receptor by VNPP433-3β in Castration-Resistant Prostate Cancer Cells Implicates Interaction with E3 Ligase MDM2 Resulting in Ubiquitin-Proteasomal Degradation.
Targeted protein degradation is a fast-evolving therapeutic strategy to target even the traditionally undruggable target proteins. Contrary to the traditional small-molecule inhibitors of enzyme...