Pierce Lab Awarded $1.5M from NIH to Model and Design Antibodies and T Cell Receptors
Researchers at the Institute for Bioscience and Biotechnology Research (IBBR) recently received $1.5M from the NIH for their project entitled, “High Resolution Modeling and Design of Immune Recognition.” Dr. Brian Pierce, IBBR Fellow, Assistant Professor in the Department of Cell Biology & Molecular Genetics at University of Maryland, College Park,...
T-Cell Based Vaccines May Be Key to Long-Term Coronavirus Immunity
The emergence of multiple variants of SARS-CoV-2 has brought major challenges to the effectiveness in vaccine development. Researchers concentrating their efforts on mutations of the virus, including Roy Mariuzza, IBBR Fellow and Professor, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park have relied heavily on the...
Anderson and Hudgens Develop New Instrument for Higher Precision Measurement of Protein Dynamics
NIST-IBBR scientists Kyle Anderson and Jeffrey Hudgens recently reported* the design and performance metrics of a new, ‘sub-zero’ dual-enzyme hydrogen deuterium exchange mass spectrometry (HDX-MS) instrument. The new HDX-MS instrument dramatically improves the precision by which protein dynamics can be measured and could enable more robust application of the technique...
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Jana Shen, Ph.D. Professor
University of Maryland School of Pharmacy, Department of Pharmaceutical Sciences
Monday, July 25, 2022 - 11:00am
Tuesday, August 16, 2022 - 11:00am
Friday, August 26, 2022 - 11:00am
Early human B cell signatures of the primary antibody response to mRNA vaccination.
Messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are highly effective at inducing protective immunity. However, weak antibody responses are seen...
Accurate modeling of RNA hairpins through the explicit treatment of electronic polarizability with the classical Drude oscillator force field.
Molecular dynamics (MD) simulations play a crucial role in modeling biomolecular systems in which the electrostatic interactions are critical in dictating the structural and dynamical properties....
Network-based redox communication between abiotic interactive materials.
Recent observations that abiotic materials can engage in redox-based interactive communication motivates the search for new redox-active materials. Here we fabricated a hydrogel from a four-armed...
Chromatography at -30 °C for Reduced Back-Exchange, Reduced Carryover, and Improved Dynamic Range for Hydrogen-Deuterium Exchange Mass Spectrometry.
For hydrogen-deuterium exchange mass spectrometry (HDX-MS) to have an increased role in quality control of biopharmaceuticals, H for D back-exchange occurring during protein analyses should be...
Large-scale synthesis of galeterone and lead next generation galeterone analog VNPP433-3β.
VNPP433-3β (compound 2, (3β-(1H-imidazole-1-yl)-17-(1H-benzimidazole-1-yl)-androsta-5,16-diene), a multitarget anticancer agent has emerged as our lead next generation galeterone analogs (NGGA)....