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Standardizing Dual-Reporter Gene Expression: The MINDR Guidelines for Reliable Data Interpretation
Dual gene expression reporter systems are widely used molecular biology tools that encode two different proteins within a synthetic mRNA sequence. Such systems play a crucial role in studying diseases, drug therapies, and cellular mechanisms. In a significant advancement, leading researchers in the field have published “Guidelines for minimal reporting...
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Congratulations to Daniel Kemboi for a Successful Dissertation Defense
IBBR proudly congratulates Daniel Kemboi for successfully defending his PhD dissertation on “The Molecular Basis for Gamma Phage Targeting” on March 11, 2025. Kemboi will complete his coursework and fulfill the requirements for the doctoral degree this month. His research, done under Dr. Daniel Nelson (IBBR Fellow), explores how bacteriophage...
Ibrahim Boyenle Receives G. Forrest Woods Memorial Scholarship and Outstanding Presentation Award at the Regional NOBCChE Meeting
Please join us in congratulating Ibrahim Boyenle, a 3rd year PhD student in Dr. Yanxin Liu’s lab (IBBR Fellow) on receiving the UMD Department of Chemistry and Biochemistry's G. Forrest Woods Memorial Scholarship. The annual award provides funds towards the educational expenses of an outstanding undergraduate or graduate student in...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Recent Publications
Conformational dynamics and multimodal interaction of Paxillin with the focal adhesion targeting domain.
Paxillin (PXN) and focal adhesion kinase (FAK) are two major components of the focal adhesion complex, a multiprotein structure linking the intracellular cytoskeleton to the cell exterior. The...
Advancing Pharmaceutical Security: Noninvasive Detection of Falsified Vaccines and Drugs Using wNMR.
OBJECTIVE
To develop and apply noninvasive analytical technologies to detect falsified vaccines and drugs.
METHODS
Univariate and multivariate methods, based on the water nuclear magnetic...
Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity.
An effective vaccine against hepatitis C virus (HCV) must elicit the production of broadly neutralizing antibodies (bnAbs) reproducibly against the E1E2 glycoprotein complex. Little is known about...
Pore formation by the CDTb component of the Clostridioides difficile binary toxin is Ca2+-dependent.
Clostridioides difficile infection (CDI) is one of the five most urgent bacterial threats in the United States. Furthermore, hypervirulent CDI strains express a third toxin termed the C. difficile...
Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein-Protein Interaction Identification in Glycoengineered CHO cells.
Hepatitis C Virus (HCV) is a bloodborne virus that affects 57 million people globally with infections that can often go unnoticed, and it is the leading cause of chronic liver disease and cancer....