Dr. John Schiel holding a figure of the NISTmAb
Excellence in Research...
IBBR scientists lead ground-breaking research, technology development and standards programs that advance and support the fields of biotechnology, biomanufacturing and human health.
A state-of-the-art SAXSLAB’s GANESHA on display here at IBBR
State-of-the-Art Methods...
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
Dr. Brian Pierce analyzing data with a figure of prostate-specific membrane antigen (PSMA) on his desk
Fostering Collaboration...
IBBR supports a dynamic research environment that facilitates interactions and collaborations between our scientists, partners, and stakeholders; promoting new research directions that complement and build on existing strengths.

Third Annual Early Career Symposium at IBBR

IBBR invites you to participate in the Third Annual Early Career Symposium at IBBR on September 12, 2024 from 8:30am-6:00pm at our facility in Rockville, Maryland. This year's symposium builds on the success of our past symposiums held in 2022 and 2023 which were attended by 150 participants from the...

IBBR Researchers Collaborate with the FDA to evaluate wNMR for Biomanufacturing Automation

Dr. Bruce Yu, IBBR Fellow and MPower Professor, of the University of Maryland, School of Pharmacy, along with Drs. Marc Taraban, Katharine Briggs, and Pallavi Guha-Biswas have been collaborating with the FDA through the Maryland-Center of Excellence in Regulatory Science and Innovation (M-CERSI) on a regulatory science challenge. The FDA...

Suruchi Singh Receives Travel Grant from American Crystallographic Association

Congratulations to Dr. Suruchi Singh, a postdoc at IBBR in the Hasan Lab, on being awarded a prestigious Travel Grant by the American Crystallographic Association (ACA) to give a talk at their upcoming 74th annual meeting. This year’s theme is “A Golden Future for Structural Science,” with aims to highlight...

About IBBR

IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.

IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.

IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.

IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.

Connecting

IBBR Commons

Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.

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IBBR Postdoc Program

The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.

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NMRPipe

IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.

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Various models of molecules
323
Current Members
165
Post-Docs Mentored
1408
Publications

Upcoming Events

Seminar

Amedee des Georges

NYU

Monday, September 9, 2024 - 11:00am

Seminar

Pin-Kuang Lai

Stevens Institute of Technology

Monday, September 30, 2024 - 11:00am

Recent Publications

Redox-mediated Biomolecular information transfer in single electrogenetic biological cells.

Electronic communication in natural systems makes use, inter alia, of molecular transmission, where electron transfer occurs within networks of redox reactions, which play a vital role in many...

Sterol-like drugs potentiate statin-triggered prostate cancer cell death by inhibiting SREBP2 nuclear translocation.

There is an urgent need to provide immediate and effective options for the treatment of prostate cancer (PCa) to prevent progression to lethal castration-resistant PCa (CRPC). The mevalonate (MVA)...

Agent-based modeling of the COVID-19 pandemic in Florida.

The onset of the COVID-19 pandemic drove a widespread, often uncoordinated effort by research groups to develop mathematical models of SARS-CoV-2 to study its spread and inform control efforts....

Deuterium spin relaxation of fractionally deuterated ribonuclease H using paired 475 and 950 MHz NMR spectrometers.

Deuterium (2H) spin relaxation of 13CH2D methyl groups has been widely applied to investigate picosecond-to-nanosecond conformational dynamics in proteins by solution-state NMR spectroscopy. The...

Mining proteomes for zinc finger persulfidation.

Hydrogen sulfide (H2S) is an endogenous gasotransmitter that signals via persulfidation. There is evidence that the cysteine residues of certain zinc finger (ZF) proteins, a common type of...