Round Robin Study Supports Adoption of Targeted Attribute Analytical Method by Biopharma
Drs. Trina Mouchahoir (NIST/IBBR) and John Schiel (NIST/IBBR Fellow) recently reported on results from a multi-attribute method (MAM) round robin study they lead together with Rich Rogers (Just - Evotec Biologics). MAM is a mass spectrometry-based measurement platform developed with an eye toward improving quality control (QC) analytics for therapeutic...
The Andrianov Lab Receives Sub-Award to Aid in the Development of a Dissolvable Microneedle Patch Vaccine against the Dangerous Nipah virus and Hendra virus
The University of Maryland - Institute for Bioscience and Biotechnology Research (IBBR) Fellow, Dr. Alexander Andrianov received a two-year $290,000 sub award from the Henry M. Jackson Foundation for the Advancement of Military Medicine on behalf of Uniformed Services University (USU) in Bethesda, MD, as part of a multi-million dollar...
IBBR Co-Director David Weber Selected as MPower Professor
Dr. David Weber, Co-Director of the Institute for Bioscience and Biotechnology Research (IBBR), Director of the Center for Biomolecular Therapeutics (CBT), Director of the Maryland Center for Advanced Molecular Analysis (M-CAMA), and a Professor in the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine,...
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Leiden University Medical Center
Tuesday, February 21, 2023 - 11:00am
Isolation protocols and mitochondrial content for plasma extracellular vesicles.
Mitochondrial content has been reported outside of cells either within extracellular vesicles (EVs) or as free mitochondria. Mitochondrial EVs can potentially play multiple physiological and...
In silico identification of a β2-adrenoceptor allosteric site that selectively augments canonical β2AR-Gs signaling and function.
Activation of β2-adrenoceptors (β2ARs) causes airway smooth muscle (ASM) relaxation and bronchodilation, and β2AR agonists (β-agonists) are front-line treatments for asthma and other...
Computer-Aided Drug Design: An Update.
Computer-aided drug design (CADD) approaches are playing an increasingly important role in understanding the fundamentals of ligand-receptor interactions and helping medicinal chemists design...
Assessing Antigen-Adjuvant Complex Stability Against Physical Stresses By wNMR.
This study applies an emerging analytical technology, wNMR (water proton nuclear magnetic resonance), to assess the stability of aluminum adjuvants and antigen-adjuvant complexes against physical...
Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity.
Antigen recognition by the T cell receptor (TCR) of CD4+ T cells can be greatly enhanced by the coreceptor CD4. Yet, understanding of the molecular mechanism is hindered by the ultra-low affinity...