IBBR Study Advances Hepatitis C Vaccine Development
Hepatitis C virus (HCV) poses a tremendous global health concern as a cause of hepatocellular carcinoma and other liver diseases, with over 58 million people infected globally and 1.5 million new infections each year. Current direct-acting antiviral drugs are effective cures but expensive and subject to viral resistance variants, posing...
Deep Learning Modeling Server for T Cells Opens New Avenues in Immunology Research
A critical component of the human immune system is T cell receptors (TCR). With their diversity and specificity, they are able to recognize and bind to antigens from viruses, pathogens, and tumors, leading to a T cell immune response against infected or diseased cells. A deeper understanding of TCR structures...
Kyle Anderson Joins Editorial Advisory Board for the Journal of the American Society for Mass Spectrometry
Kyle Anderson was invited by the Editor-in-Chief, Vicki Wysocki, of the Journal of the American Society for Mass Spectrometry (JASMS) to join the Editorial Advisory Board. He was selected because he has been a frequent contributor and reliable reviewer for JASMS, and JASMS leadership hopes he will provide further valuable...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
BMD Staff Seminar B. Steffen/K. Anderson, .06/.07
B. Steffen/K. Anderson, .06/.07
Tuesday, December 12, 2023 - 11:00am
Wednesday, December 13, 2023 - 11:00am
Wednesday, December 20, 2023 - 11:00am
Recent Publications
Structural basis for T cell recognition of cancer neoantigens and implications for predicting neoepitope immunogenicity.
Adoptive cell therapy (ACT) with tumor-specific T cells has been shown to mediate durable cancer regression. Tumor-specific T cells are also the basis of other therapies, notably cancer vaccines....
Characterizing Adeno-Associated Virus Capsids with Both Denaturing and Intact Analysis Methods.
Adeno-associated virus (AAV) capsids are among the leading gene delivery platforms used to treat a vast array of human diseases and conditions. AAVs exist in a variety of serotypes due to...
Hydrogen-Deuterium Exchange Dynamics of NISTmAb Measured by Small Angle Neutron Scattering.
Understanding protein dynamics and conformational stability holds great significance in biopharmaceutical research. Hydrogen-deuterium exchange (HDX) is a quantitative methodology used to examine...
Cryo-EM and AFM visualize linear polyorganophosphazene: individual chains and single-chain assemblies with proteins.
Polyorganophosphazenes are biodegradable macromolecules with potent immunoadjuvant activity that self-assemble with protein antigens to provide biological activity. Direct imaging by cryogenic...
Leaf abaxial immunity to powdery mildew in Arabidopsis is conferred by multiple defense mechanisms.
Powdery mildew (PM) fungi are obligate biotrophic pathogens that only invade plant epidermal cells. There are two epidermal surfaces for any plant leaves: the adaxial (upper) side and the abaxial...