Areas of Focus

Biomolecular Engineering
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Disease Pathways and Biomolecular Targets
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Host-Pathogen Interactions
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Biomolecular Measurement Sciences
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Upcoming Events

News Releases

  • Decade of TMV research leads to never-before-seen microsystems for energy storage, biosensors and self-sustaining systems
  • IBBR Awarded $6 Million NIH Grant for Structure-Based Design of a Hepatitis C Vaccine
  • IBBR faculty win two Maryland Innovation Initiative (MII) grants
  • Genisphere Begins Collaborative and Sponsored Research Program with the University of Maryland

Recent Publications

  • Application of 2D-NMR with room temperature NMR probes for the assessment of the higher order structure of filgrastim.
  • Biofabrication of Tobacco mosaic virus-nanoscaffolded supercapacitors via temporal capillary microfluidics.
  • In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds.
  • Enhanced Delivery and Effects of Acid Sphingomyelinase by ICAM-1-Targeted Nanocarriers in Type B Niemann-Pick Disease Mice.
  • PCPP-Adjuvanted Respiratory Syncytial Virus (RSV) sF Subunit Vaccine: Self-Assembled Supramolecular Complexes Enable Enhanced Immunogenicity and Protection.
  • A protein-protein interaction dictates Borrelial infectivity.
  • Ensemble variant interpretation methods to predict enzyme activity and assign pathogenicity in the CAGI4 NAGLU (Human N-acetyl-glucosaminidase) and UBE2I (Human SUMO-ligase) challenges.
  • Matching phenotypes to whole genomes: Lessons learned from four iterations of the personal genome project community challenges.
  • Biodegradable "Smart" Polyphosphazenes with Intrinsic Multi-Functionality as Intracellular Protein Delivery Vehicles.
  • Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability.
  • Structural characterization of membrane-bound human immunodeficiency virus-1 Gag matrix with neutron reflectometry.
  • CAGI4 SickKids clinical genomes challenge: A pipeline for identifying pathogenic variants.
  • CAGI4 Crohn's exome challenge: Marker SNP versus exome variant models for assigning risk of Crohn disease.
  • Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.
  • Determination of disease phenotypes and pathogenic variants from exome sequence data in the CAGI 4 gene panel challenge.