Pierce Lab Awarded $1.5M from NIH to Model and Design Antibodies and T Cell Receptors
Researchers at the Institute for Bioscience and Biotechnology Research (IBBR) recently received $1.5M from the NIH for their project entitled, “High Resolution Modeling and Design of Immune Recognition.” Dr. Brian Pierce, IBBR Fellow, Assistant Professor in the Department of Cell Biology & Molecular Genetics at University of Maryland, College Park,...
IBBR Researchers Discover Ribosome from the Human Parasite Giardia lamblia May Provide Promising Therapeutic Target in Combating Giardiasis
Giardiasis is an acute human diarrheal disease caused by the microscopic parasite Giardia lamblia (GL) that persists in the environment and causes much suffering when ingested through contaminated water and food. Giardiasis also increases the probability of developing irritable bowel syndrome later in life. New strategies to combat Giardiasis need...
IBBR Postdoc Debajit Dey Receives Scholar Travel Award from American Society for Virology (ASV)
The American Society for Virology (ASV) has awarded their nationally competitive Postdoctoral Scholar Travel Award to Debajit Dey, a Postdoctoral Fellow in the Hasan lab at IBBR/University of Maryland, School of Medicine. Dey is a member of the IBBR Postdoctoral Program (IPP), and he will travel to the upcoming ASV...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
IBBR/NIST BMD Seminar: “Making Heme: Impossible Foods' Key Ingredient”
Smita Shankar
Impossible Foods
Tuesday, May 31, 2022 - 2:00pm
Gillian Tully
King's College London
Tuesday, June 7, 2022 - 11:00am
IBBR/NIST Seminar: Brian Pierce
Tuesday, June 14, 2022 - 11:00am
Recent Publications
Hierarchically Structured, All-Aqueous-Coated Hydrophobic Surfaces with pH-Selective Droplet Transfer Capability.
Often inspired by nature, techniques for precise droplet manipulation have found applications in microfluidics, microreactors, and water harvesting. However, a widely applicable strategy for...
Interlaboratory Studies Using the NISTmAb to Advance Biopharmaceutical Structural Analytics.
Biopharmaceuticals such as monoclonal antibodies are required to be rigorously characterized using a wide range of analytical methods. Various material properties must be characterized and well...
Conformational dynamics of the hepatitis B virus pre-genomic RNA on multiple time scales: implications for viral replication.
Human hepatitis B virus (HBV) replication is initiated by the binding of the viral polymerase (P) to epsilon (ε), an ≈85-nucleotide (nt) cis-acting regulatory stem-loop RNA located at the...
Metallated Anticancer Peptides: An Expanded Mechanism that Encompasses Physical and Chemical Bilayer Disruption.
In the search for novel broad-spectrum therapeutics to fight chronic infections, inflammation, and cancer, host defense peptides (HDPs) have garnered increasing interest. Characterizing their...
In Silico Identification of a β2 Adrenergic Receptor Allosteric Site that Selectively Augments Canonical β2 AR-Gs Signaling and Function.
OBJECTIVE & HYPOTHESIS
Activation of β2 -adrenergic receptors (β2 ARs) leads to airway smooth muscle (ASM) relaxation and bronchodilation. While this facilitates β2 ARs agonists (β-agonists) as...