IBBR Study Advances Hepatitis C Vaccine Development
Hepatitis C virus (HCV) poses a tremendous global health concern as a cause of hepatocellular carcinoma and other liver diseases, with over 58 million people infected globally and 1.5 million new infections each year. Current direct-acting antiviral drugs are effective cures but expensive and subject to viral resistance variants, posing...
Panic Webinar on March 12
Join us for a webinar on March 12 at 11 am presented by PANIC and Bruker. Participants will have the opportunity to learn about oligonucleotides and NMR. Visit www.panicnmr.com to register.
Kyle Anderson Receives 2023 U.S. Department of Commerce Bronze Medal for Developing Novel HDX-MS Methods that Improve Understanding of Protein-based Drugs
NIST-IBBR scientist Kyle Anderson is the recipient of a 2023 U.S. Department of Commerce Bronze Medal. He is recognized for developing novel hydrogen-exchange mass-spectrometry methods that improve understanding of the structure and activity of protein-based drugs. The award citation reads, “Dr. Anderson is honored for developing novel improvements to the...
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
H. Habra/K. Gettings, .04/.06
Tuesday, March 5, 2024 - 11:00am
Wednesday, March 6, 2024 - 11:00am
Monday, March 11, 2024 - 11:00am
Engineering Degradation Rate of Polyphosphazene-Based Layer-by-Layer Polymer Coatings.
Degradable layer-by-layer (LbL) polymeric coatings have distinct advantages over traditional biomedical coatings due to their precision of assembly, versatile inclusion of bioactive molecules, and...
Transcription factors VviWRKY10 and VviWRKY30 co-regulate powdery mildew resistance in grapevine.
Grapevine (Vitis vinifera) is an economically important fruit crop worldwide. The widely cultivated grapevine is susceptible to powdery mildew caused by Erysiphe necator. In this study, we used...
CRISPR-targeted mutagenesis of mitogen-activated protein kinase phosphatase 1 improves both immunity and yield in wheat.
Plants have evolved a sophisticated immunity system for specific detection of pathogens and rapid induction of measured defences. Over- or constitutive activation of defences would negatively...
Effect of Acetylation on the Nanofibril Formation of Chitosan from All-Atom De Novo Self-Assembly Simulations.
Chitosan-based materials have broad applications, from biotechnology to pharmaceutics. Recent experiments showed that the degree and pattern of acetylation along the chitosan chain modulate its...
In-situ biophysical characterization of high-concentration protein formulations using wNMR.
High-concentration protein formulation is of paramount importance in patient-centric drug product development, but it also presents challenges due to the potential for enhanced aggregation and...