Pierce Lab Awarded $1.5M from NIH to Model and Design Antibodies and T Cell Receptors
Researchers at the Institute for Bioscience and Biotechnology Research (IBBR) recently received $1.5M from the NIH for their project entitled, “High Resolution Modeling and Design of Immune Recognition.” Dr. Brian Pierce, IBBR Fellow, Assistant Professor in the Department of Cell Biology & Molecular Genetics at University of Maryland, College Park,...
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T-Cell Based Vaccines May Be Key to Long-Term Coronavirus Immunity
The emergence of multiple variants of SARS-CoV-2 has brought major challenges to the effectiveness in vaccine development. Researchers concentrating their efforts on mutations of the virus, including Roy Mariuzza, IBBR Fellow and Professor, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park have relied heavily on the...
IBBR Postdoc Debajit Dey Receives Scholar Travel Award from American Society for Virology (ASV)
The American Society for Virology (ASV) has awarded their nationally competitive Postdoctoral Scholar Travel Award to Debajit Dey, a Postdoctoral Fellow in the Hasan lab at IBBR/University of Maryland, School of Medicine. Dey is a member of the IBBR Postdoctoral Program (IPP), and he will travel to the upcoming ASV...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
IBBR/NIST Seminar: "Facilitating the Development and Availability of COVID-19 Vaccines"
Peter Marks
FDA
Monday, June 27, 2022 - 11:00am
Jana Shen, Ph.D. Professor
TBD
University of Maryland School of Pharmacy, Department of Pharmaceutical Sciences
Monday, July 25, 2022 - 11:00am
Tuesday, August 16, 2022 - 11:00am
Recent Publications
Chromatography at -30 °C for Reduced Back-Exchange, Reduced Carryover, and Improved Dynamic Range for Hydrogen-Deuterium Exchange Mass Spectrometry.
For hydrogen-deuterium exchange mass spectrometry (HDX-MS) to have an increased role in quality control of biopharmaceuticals, H for D back-exchange occurring during protein analyses should be...
Large-scale synthesis of galeterone and lead next generation galeterone analog VNPP433-3β.
VNPP433-3β (compound 2, (3β-(1H-imidazole-1-yl)-17-(1H-benzimidazole-1-yl)-androsta-5,16-diene), a multitarget anticancer agent has emerged as our lead next generation galeterone analogs (NGGA)....
MYB308-mediated transcriptional activation of plasma membrane H + -ATPase 6 promotes iron uptake in citrus.
Iron-deficiency chlorosis is a common nutritional disorder in crops grown on alkaline or calcareous soils. Although the acclimation mechanism to iron deficiency has been investigated, the genetic...
Novel deuterated Mnk1/2 protein degrader VNLG-152R analogs: Synthesis, In vitro Anti-TNBC activities and pharmacokinetics in mice.
A new and improved synthesis of lead Mnk1/2 protein degrader, VNLG-152R, 4-(±)-(1H-imidazole-1-yl)-N-(4-fluorophenyl)-(E)-retinamide (1) has been developed from commercially available 4-oxo-ATRA...
Structural and biophysical properties of farnesylated KRas interacting with the chaperone SmgGDS-558.
KRas is a small GTPase and membrane-bound signaling protein. Newly synthesized KRas is post-translationally modified with a membrane-anchoring prenyl group. KRas chaperones are therapeutic targets...