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Mass Spec-CryoEM Symposium at IBBR - October 10th - Register Today!
IBBR will host a one-day Thermo Fisher sponsored symposium, "Bound Together: Mass Spectrometry and Cryo-EM", on Tuesday, October 10th. This will include talks on the development of new MS and Cryo-EM methods and synergistic use of these tools to address biological questions. The keynote speaker is Dr. Ganesh Anand from...
Deep Learning Modeling Server for T Cells Opens New Avenues in Immunology Research
A critical component of the human immune system is T cell receptors (TCR). With their diversity and specificity, they are able to recognize and bind to antigens from viruses, pathogens, and tumors, leading to a T cell immune response against infected or diseased cells. A deeper understanding of TCR structures...
Second Early Career Symposium at IBBR
In honor of Postdoc Appreciation Week, the Institute for Bioscience and Biotechnology Research recently hosted their Second Annual Early Career Symposium at IBBR. Over 120 attendees from the University System of Maryland, NIST, NIH, FDA, Johns Hopkins, AstraZeneca and many more gathered for a day of scientific research, a poster...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
Seminar: “Streamlined Comparability Assessment of an Array of Therapeutic Antibodies”
Belinda Pastrana
CEO and Founder
Protein Dynamic Solutions, LLC
Tuesday, October 3, 2023 - 11:00am
Tuesday, October 17, 2023 - 11:00am
Seminar: "Artificial Intelligence Tools for Antibody Engineering and Protein Docking"
Jeff Gray
Professor of Chemical and Biomolecular Engineering
Johns Hopkins University
Monday, October 23, 2023 - 11:00am
Recent Publications
VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2.
Triple-negative breast cancer (TNBC) and its recently identified subtype, quadruple negative breast cancer (QNBC), collectively account for approximately 13% of reported breast cancer cases in the...
Role of the Lactide:Glycolide Ratio in PLGA Nanoparticle Stability and Release under Lysosomal Conditions for Enzyme Replacement Therapy of Lysosomal Storage Disorders.
Prior studies demonstrated that encapsulation in poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) enhanced the delivery of enzymes used for replacement therapy (ERT) of lysosomal storage...
Role of Domain-Domain Interactions on the Self-Association and Physical Stability of Monoclonal Antibodies: Effect of pH and Salt.
Monoclonal antibodies (mAbs) make up a major class of biotherapeutics with a wide range of clinical applications. Their physical stability can be affected by various environmental factors. For...
Neuroimaging in insomnia: Review and reconsiderations.
Over the last decades, neuroimaging has become a substantial component of insomnia research. While theoretical underpinnings of different studies vary just like methodological choices and the...
Screening in serum-derived medium reveals differential response to compounds targeting metabolism.
A challenge for screening new anticancer drugs is that efficacy in cell culture models is not always predictive of efficacy in patients. One limitation of standard cell culture is a reliance on...