Alexander Andrianov

Research Professor

Andrianov Group



Call: (240) 314-6456


  • Postdoctoral Research, Chemical Engineering, Massachusetts Institute of Technology (MIT), 1991-1993
  • Ph.D., Polymer Science, Moscow State University, 1985
  • B.S., Chemistry, Moscow State University, 1980


Dr. Alexander Andrianov is a leader in the field of polyphosphazenes with a long-standing interest in applications of polymers for drug delivery systems and biomaterials. He has been involved in all aspects of technology development and commercialization, including product advancement from the research laboratory to manufacturing and clinical trials. Dr. Andrianov has served in various executive and managerial roles at a number of biotechnology companies focusing on drug delivery technologies and biomaterials, and he has worked as a biotechnology consultant to industrial, academic, and global health organizations.


The Andrianov lab uses the polyphosphazene technology platform to develop novel materials for life sciences applications and studies interactions of these macromolecules with biologically important targets. Current projects include the development of potent macromolecular immunomodulators and vaccine delivery vehicles, biodegradable nanoparticulate drug delivery carriers with built-in ‘smart’ intracellular delivery functions, non-covalent PEGylation systems for extending protein half-life, and novel polyelectrolytes for aqueous layer-by-layer assembly of biocompatible, self-healing, fluorinated coatings.

The lab integrates expertise in rational design, controlled synthesis and scaled-up production of these macromolecules, as well as precise formulation and nanofabrication methods. It is equipped with state-of-the-art equipment and expertise for screening macromolecules for critical parameters such as biocompatibility and interactions with important protein targets.


Polyphosphazenes for vaccine and drug delivery

Polyphosphazene biomaterials
Fluorine-Functionalized Polyphosphazene Immunoadjuvant: Synthesis, Solution Behavior and In Vivo Potency.
Noncovalent PEGylation of protein and peptide therapeutics.
4-Methylumbelliferone-Functionalized Polyphosphazene and Its Assembly into Biocompatible Fluorinated Nanocoatings with Selective Antiproliferative Activity.
Skin Vaccination with Ebola Virus Glycoprotein Using a Polyphosphazene-Based Microneedle Patch Protects Mice against Lethal Challenge.
Factors Controlling Degradation of Biologically Relevant Synthetic Polymers in Solution and Solid State.
Polyphosphazene: A New Adjuvant Platform for Cocaine Vaccine Development.
Hierarchically Structured, All-Aqueous-Coated Hydrophobic Surfaces with pH-Selective Droplet Transfer Capability.
Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate.
Cationic Fluoropolyphosphazenes: Synthesis and Assembly with Heparin as a Pathway to Hemocompatible Nanocoatings.
Nano-Assembly of Quisinostat and Biodegradable Macromolecular Carrier Results in Supramolecular Complexes with Slow-Release Capabilities.
Immunopotentiating and Delivery Systems for HCV Vaccines.
Supramolecular assembly of Toll-like receptor 7/8 agonist into multimeric water-soluble constructs enables superior immune stimulation in vitro and in vivo.
Intracellular Delivery of Active Proteins by Polyphosphazene Polymers.
Improvement of RG1-VLP vaccine performance in BALB/c mice by substitution of alhydrogel with the next generation polyphosphazene adjuvant PCEP.
Next generation polyphosphazene immunoadjuvant: Synthesis, self-assembly and in vivo potency with human papillomavirus VLPs-based vaccine.
Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer.
Polyphosphazenes enable durable, hemocompatible, highly efficient antibacterial coatings.
Polyphosphazene immunoadjuvants: Historical perspective and recent advances.
Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.
In Vivo and In Vitro Potency of Polyphosphazene Immunoadjuvants with Hepatitis C Virus Antigen and the Role of Their Supramolecular Assembly.