Jonathan Dinman

Professor and Director of IBBR

Dinman Group

Contact

Email: dinman@umd.edu

Call: (240) 314-6373

Profile

Jonathan Dinman became the Director of the Institute for Bioscience and Biotechnology Research (IBBR) in November, 2024. He is a Professor in the Department of Cell Biology and Molecular Genetics at the University of Maryland, College Park, where he has taught virology, RNA Biology and a University Honors class exploring the influence of globalization and climate change on infectious diseases. Dr. Dinman was previously the Director of the MOCB graduate program, Chair of CBMG, and a Fellow in the NSF ADVANCE program and the Honors College. Dr. Dinman graduated from Oberlin College in 1980 and completed a Ph.D. in Immunology and Infectious Diseases from Johns Hopkins School of Hygiene and Public Health in 1988 followed by a post-doctoral fellowship from 1988 to 1995 at the National Institutes of Health. Dr. Dinman’s research focuses on the control of gene expression at the level of protein synthesis, with emphasis on virology, ribosome structure/function relationships, and human disease.

Publications
2025
Plasticity of the mammalian integrated stress response.
RETRACTED: Dahal et al. PERK Is Critical for Alphavirus Nonstructural Protein Translation. Viruses 2021, 13, 892.
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR).
2023
Shiftless Is a Novel Member of the Ribosome Stress Surveillance Machinery That Has Evolved to Play a Role in Innate Immunity and Cancer Surveillance.
Correction: A novel de novo variant in CASK causes a severe neurodevelopmental disorder that masks the phenotype of a novel de novo variant in EEF2.
A novel de novo variant in CASK causes a severe neurodevelopmental disorder that masks the phenotype of a novel de novo variant in EEF2.
2022
Deep mutational analysis of elongation factor eEF2 residues implicated in human disease to identify functionally important contacts with the ribosome.
Biomotors, viral assembly, and RNA nanobiotechnology: Current achievements and future directions.
Response to: Lack of evidence for ribosomal frameshifting in ATP7B mRNA decoding.
EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell Death.
Identifying Inhibitors of -1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses.
2021
PERK Is Critical for Alphavirus Nonstructural Protein Translation.
Programmed -1 Ribosomal Frameshifting in coronaviruses: A therapeutic target.
2020
De Novo variants in EEF2 cause a neurodevelopmental disorder with benign external hydrocephalus.
Two Ribosomes Are Better Than One... Sometimes.
Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS-CoV-2.
Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2).
2019
Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism.
EGR1 upregulation following Venezuelan equine encephalitis virus infection is regulated by ERK and PERK pathways contributing to cell death.
The Expanding Riboverse.