Jonathan Dinman
Professor and Director of IBBR
Dinman Group (240) 314-6373 dinman@umd.eduJonathan Dinman became the Director of the Institute for Bioscience and Biotechnology Research (IBBR) in November, 2024. He is a Professor in the Department of Cell Biology and Molecular Genetics at the University of Maryland, College Park, where he has taught virology, RNA Biology and a University Honors class exploring the influence of globalization and climate change on infectious diseases. Dr. Dinman was previously the Director of the MOCB graduate program, Chair of CBMG, and a Fellow in the NSF ADVANCE program and the Honors College. Dr. Dinman graduated from Oberlin College in 1980 and completed a Ph.D. in Immunology and Infectious Diseases from Johns Hopkins School of Hygiene and Public Health in 1988 followed by a post-doctoral fellowship from 1988 to 1995 at the National Institutes of Health. Dr. Dinman’s research focuses on the control of gene expression at the level of protein synthesis, with emphasis on virology, ribosome structure/function relationships, and human disease.
Publications
- Translon: a single term for translated regions.
- Plasticity of the mammalian integrated stress response.
- RETRACTED: Dahal et al. PERK Is Critical for Alphavirus Nonstructural Protein Translation. Viruses 2021, 13, 892.
- Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR).
- Shiftless Is a Novel Member of the Ribosome Stress Surveillance Machinery That Has Evolved to Play a Role in Innate Immunity and Cancer Surveillance.
- Correction: A novel de novo variant in CASK causes a severe neurodevelopmental disorder that masks the phenotype of a novel de novo variant in EEF2.
- A novel de novo variant in CASK causes a severe neurodevelopmental disorder that masks the phenotype of a novel de novo variant in EEF2.
- Deep mutational analysis of elongation factor eEF2 residues implicated in human disease to identify functionally important contacts with the ribosome.
- Biomotors, viral assembly, and RNA nanobiotechnology: Current achievements and future directions.
- Response to: Lack of evidence for ribosomal frameshifting in ATP7B mRNA decoding.
- EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell Death.
- Identifying Inhibitors of -1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses.
- De Novo variants in EEF2 cause a neurodevelopmental disorder with benign external hydrocephalus.
- Two Ribosomes Are Better Than One... Sometimes.
- Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS-CoV-2.
- Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2).
- Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism.
- EGR1 upregulation following Venezuelan equine encephalitis virus infection is regulated by ERK and PERK pathways contributing to cell death.
- The Expanding Riboverse.
- Slippery ribosomes prefer shapeshifting mRNAs.
- Translational recoding signals: Expanding the synthetic biology toolbox.
- Scaring Ribosomes Shiftless.
- Still Searching for Specialized Ribosomes.
- Ribosomal Lesions Promote Oncogenic Mutagenesis.
- Shapeshifting RNAs guide innate immunity.
- Functional and structural characterization of the chikungunya virus translational recoding signals.
- Translation Elongation and Recoding in Eukaryotes.
- CCR5 RNA Pseudoknots: Residue and Site-Specific Labeling correlate Internal Motions with microRNA Binding.
- How Ribosomes Translate Cancer.
- Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus.
- Subtractional Heterogeneity: A Crucial Step toward Defining Specialized Ribosomes.
- Tracking fluctuation hotspots on the yeast ribosome through the elongation cycle.
- A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism.
- Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene.
- Ablation of Programmed -1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity.
- Structural and Functional Characterization of Programmed Ribosomal Frameshift Signals in West Nile Virus Strains Reveals High Structural Plasticity Among cis-Acting RNA Elements.
- The Functional Role of eL19 and eB12 Intersubunit Bridge in the Eukaryotic Ribosome.
- Ribosomal protein uS19 mutants reveal its role in coordinating ribosome structure and function.
- Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1.
- Pathways to Specialized Ribosomes: The Brussels Lecture.
- Reprogramming the genetic code: The emerging role of ribosomal frameshifting in regulating cellular gene expression.
- Cell cycle control (and more) by programmed -1 ribosomal frameshifting: implications for disease and therapeutics.
- Ribosomopathies and the paradox of cellular hypo- to hyperproliferation.
- Small molecule inhibitors of Ago2 decrease Venezuelan equine encephalitis virus replication.
- Trajectories of the ribosome as a Brownian nanomachine.
- Molecular biology: Entry signals control development.
- Ribosomes in the balance: structural equilibrium ensures translational fidelity and proper gene expression.
- Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway.
- Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesis.
- Yeast telomere maintenance is globally controlled by programmed ribosomal frameshifting and the nonsense-mediated mRNA decay pathway.
- A new system for naming ribosomal proteins.
- Single-molecule measurements of the CCR5 mRNA unfolding pathways.
- rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells.
- Chromatographic purification of highly active yeast ribosomes.
- Evolution of a helper virus-derived, ribosome binding translational enhancer in an untranslated satellite RNA of Turnip crinkle virus.
- An extensive network of information flow through the B1b/c intersubunit bridge of the yeast ribosome.
- A rapid, inexpensive yeast-based dual-fluorescence assay of programmed--1 ribosomal frameshifting for high-throughput screening.
- The central core region of yeast ribosomal protein L11 is important for subunit joining and translational fidelity.
- High throughput structural analysis of yeast ribosomes using hSHAPE.
- Mutations of highly conserved bases in the peptidyltransferase center induce compensatory rearrangements in yeast ribosomes.
- Ribosome binding to a 5' translational enhancer is altered in the presence of the 3' untranslated region in cap-independent translation of turnip crinkle virus.
- Endogenous ribosomal frameshift signals operate as mRNA destabilizing elements through at least two molecular pathways in yeast.
- A flexible loop in yeast ribosomal protein L11 coordinates P-site tRNA binding.
- A molecular clamp ensures allosteric coordination of peptidyltransfer and ligand binding to the ribosomal A-site.
- Enhanced purity, activity and structural integrity of yeast ribosomes purified using a general chromatographic method.
- Ribosomal protein L3 functions as a 'rocker switch' to aid in coordinating of large subunit-associated functions in eukaryotes and Archaea.
- The 3' proximal translational enhancer of Turnip crinkle virus binds to 60S ribosomal subunits.
- Yeast ribosomal protein L10 helps coordinate tRNA movement through the large subunit.
- PRFdb: a database of computationally predicted eukaryotic programmed -1 ribosomal frameshift signals.
- Structure/function analysis of yeast ribosomal protein L2.
- rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance.
- Evaluation of microwave-accelerated residue-specific acid cleavage for proteomic applications.
- 5S rRNA: Structure and Function from Head to Toe.
- Integration of residue-specific acid cleavage into proteomic workflows.
- Differentiating between near- and non-cognate codons in Saccharomyces cerevisiae.
- Programmed Ribosomal Frameshifting Goes Beyond Viruses: Organisms from all three kingdoms use frameshifting to regulate gene expression, perhaps signaling a paradigm shift.
- Ribosomal protein L3: gatekeeper to the A site.
- Optimization of ribosome structure and function by rRNA base modification.
- Ribosomal protein L3: influence on ribosome structure and function.
- Identification of functional, endogenous programmed -1 ribosomal frameshift signals in the genome of Saccharomyces cerevisiae.
- An arc of unpaired "hinge bases" facilitates information exchange among functional centers of the ribosome.
- Efficient expression of the 15-kDa form of infectious pancreatic necrosis virus VP5 by suppression of a UGA codon.
- Specific effects of ribosome-tethered molecular chaperones on programmed -1 ribosomal frameshifting.
- Comparative study of the effects of heptameric slippery site composition on -1 frameshifting among different eukaryotic systems.
- Decreased peptidyltransferase activity correlates with increased programmed -1 ribosomal frameshifting and viral maintenance defects in the yeast Saccharomyces cerevisiae.
- Delayed rRNA processing results in significant ribosome biogenesis and functional defects.
- The 9-A solution: how mRNA pseudoknots promote efficient programmed -1 ribosomal frameshifting.